Results 51 to 60 of about 301,615 (262)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
THE GOLDEN STANDARD TYPE Ia SUPERNOVA 2005cf: OBSERVATIONS FROM THE ULTRAVIOLET TO THE NEAR-INFRARED WAVEBANDS [PDF]
, 2008 We present extensive photometry at ultraviolet (UV), optical, and near-infrared (NIR) wavelengths, as well as dense sampling of optical spectra, for the normal Type Ia supernova (SN Ia) 2005cf.
Xiaofeng Wang +45 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Iterated learning and grounding: from holistic to compositional languages [PDF]
, 2003 This paper presents a new computational model for studying the origins and evolution of compositional languages grounded through the interaction between agents and their environment.
Vogt, Paul
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Crystalline silicate dust around evolved stars. I. The sample stars [PDF]
, 2002 This is the rst paper in a series of three where we present the rst comprehensive inventory of solid state emission bands observed in a sample of 17 oxygen-rich circumstellar dust shells surrounding evolved stars.
F. Molster +11 more
semanticscholar +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Internal Properties of Ultracompact Dwarf Galaxies in the Virgo Cluster [PDF]
, 2006 We present new imaging and spectroscopic observations of six ultracompact dwarf (UCD) galaxies in the Virgo Cluster, along with reanalyzed data for five Fornax Cluster UCDs. These are the most luminous UCDs: -14 mag < MV < -12 mag.
E. Evstigneeva +6 more
semanticscholar +1 more source
(WP 2018-03) Comment on White on the Relationship between Economics and Ethics [PDF]
, 2018 This short comment on Mark White’s comment on the relationship of economics and ethics focuses on the nature of economics and ethics as an emergent field of investigation.
Davis, John B.
core +1 more source