Results 1 to 10 of about 5,568 (184)

Application of the PET ligand [11C]ORM-13070 to examine receptor occupancy by the α2C-adrenoceptor antagonist ORM-12741: translational validation of target engagement in rat and human brain

open access: yesEJNMMI Research, 2020
Background Availability of the α2C-adrenoceptor (α2C-AR) positron emission tomography (PET) tracer, [11C]ORM-13070, and the α2C-AR antagonist ORM-12741 allows probing of the roles of this G-protein coupled receptor subtype in brain function, both in ...
Juha Rinne, Mika Scheinin, Olof Solin
exaly   +2 more sources

CaMKII modulates memory destabilization by regulating the interaction of theta and gamma oscillations [PDF]

open access: yesFrontiers in Cellular Neuroscience
Object recognition memory (ORM) allows animals to distinguish between novel and familiar items. When reactivated during recall in the presence of a novel object, a consolidated ORM can be destabilized and linked to that generated by the novel object ...
Janine I. Rossato   +8 more
doaj   +2 more sources

Impaired odor recognition memory in Parkinson’s disease linked to absent functional hippocampal asymmetry [PDF]

open access: yesnpj Parkinson's Disease
Odor recognition memory (ORM) combines olfaction and episodic memory, both linked to dementia and impaired in Parkinson’s Disease (PD). Measuring ORM may indicate early PD dementia and aid in selecting device-aided Parkinson therapy.
Tom Eek   +5 more
doaj   +2 more sources

On the effect of hippocampal c-Jun N-terminal kinase inhibition on object recognition memory

open access: yesFrontiers in Behavioral Neuroscience, 2022
c-Jun N-terminal kinase (JNK) phosphorylates the transcription factor c-Jun in response to stress stimuli and contributes to both hippocampal synaptic plasticity and memory processing in mammals.
Janine I. Rossato   +7 more
doaj   +1 more source

Modified Signaling of Membrane Formyl Peptide Receptors in NADPH-Oxidase Regulation in Obesity-Resistant Mice

open access: yesMembranes, 2023
The signaling of membrane receptors is modified in obesity characterized by low-grade inflammation. The obesity-resistant state of organisms is poorly understood.
Irina Tikhonova   +3 more
doaj   +1 more source

The problem of a hydrogen atom in a cavity: Oscillator representation solution versus analytic solution

open access: yesOpen Physics, 2021
A solution to the problem of a hydrogenic atom in a homogeneous dielectric medium with a concentric spherical cavity using the oscillator representation method (ORM) is presented.
Chaudhuri Sid
doaj   +1 more source

Interaction Analysis Based on Shapley Values and Extreme Gradient Boosting: A Realistic Simulation and Application to a Large Epidemiological Prospective Study

open access: yesFrontiers in Nutrition, 2022
BackgroundSHapley Additive exPlanations (SHAP) based on tree-based machine learning methods have been proposed to interpret interactions between exposures in observational studies, but their performance in realistic simulations is seldom evaluated ...
Nicola Orsini   +3 more
doaj   +1 more source

ORM in dynamic languages [PDF]

open access: yesCommunications of the ACM, 2009
Dynamic languages offer a taste of object-relational mapping that eases application code.
openaire   +1 more source

Comparative analysis of selected object-relational mapping systems for the .NET platform

open access: yesJournal of Computer Sciences Institute, 2020
This article is devoted to the comparison of two object-relational mapping systems supported by .NET platform - Entity Framework Core and NHibernate.
Krzysztof Drzazga   +2 more
doaj   +1 more source

Reduction Transformations in ORM [PDF]

open access: yes, 2007
This paper proposes extensions to the Object-Role Modeling approach to support schema transformations that eliminate unneeded columns that may arise from standard relational mapping procedures. A "unique where true" variant of the external uniqueness constraint is introduced to allow roles spanned by such constraints to occur in unary fact types.
Terry A. Halpin   +2 more
openaire   +1 more source

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