Results 51 to 60 of about 5,568 (184)

Optogenetic inactivation of the medial septum impairs long-term object recognition memory formation

open access: yesMolecular Brain, 2022
Theta is one of the most prominent extracellular synchronous oscillations in the mammalian brain. Hippocampal theta relies on an intact medial septum (MS) and has been consistently recorded during the training phase of some learning paradigms, suggesting
Maria Carolina Gonzalez   +5 more
doaj   +1 more source

When NCX switches sides: Experimental and computational insights into Ca2+ regulation in the heart

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Due to its presence inside the dyadic cleft, Na+/Ca2+ exchanger (NCX) builds a functional unit together with L‐type calcium channels and ryanodine receptors in the dyadic cleft. NCX acts bidirectionally (forward and reverse mode) dependent on extracellular calcium ([Ca2+]o) and sodium ([Na+]o) concentrations and the membrane ...
Wilhelm Neubert   +6 more
wiley   +1 more source

Prostate Cancer Development, Progression, and Therapy

open access: yesMedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin   +9 more
wiley   +1 more source

A Systematic Review and Taxonomy of Fall Detection in Geriatric Care: Current State, Challenges, and Applications

open access: yesWIREs Data Mining and Knowledge Discovery, Volume 16, Issue 3, September 2026.
Overview of fall‐detection approaches and technologies in geriatric care. ABSTRACT This systematic review provides a critical examination of fall detection (FD) technologies in geriatric care, analyzing both technological innovations and implementation challenges across diverse healthcare environments.
Hamid Ali   +6 more
wiley   +1 more source

Studi Komparasi Kinerja Object-Relational Mapping Berdasarkan Implementasi Data Source Architectural Pattern

open access: yesJurnal Nasional Teknik Elektro dan Teknologi Informasi
Object-relational mapping (ORM) merupakan teknik pemetaan (mapping) antara in-memory objects dan tabel pada basis data. ORM mengimplementasi data source architectural patterns (DSAP), di antaranya Data Mapper dan Active Record.
Muhammad Rezy Anshari   +4 more
doaj   +1 more source

Antibody–Drug Conjugates and Peptide–Drug Conjugates: Current Understandings and Future Perspectives

open access: yesMedComm, Volume 7, Issue 8, August 2026.
The graphic summarizes the design principles, intracellular trafficking, clinical progress, challenges, and future directions of antibody–drug conjugates (ADCs) and peptide–drug conjugates (PDCs). ADCs consist of a tumor‐targeting antibody, a chemical linker, and a potent payload, whereas PDCs use peptide ligands to deliver cytotoxic, radionuclide, or ...
Ruxi Zheng   +9 more
wiley   +1 more source

Establishment of mine three-dimensional spatial data model

open access: yesMeikuang Anquan
Aiming at the problems of low efficiency of coal mine data utilization and less data sharing caused by the lack of standardized coal mine data model, this paper studies the three-dimensional spatial multivariate data relationship and attribute data ...
Yannan HAN
doaj   +1 more source

Performance Evaluation of Java Based Object Relational Mapping Tools [PDF]

open access: yesMehran University Research Journal of Engineering and Technology, 2013
Object persistency is the hot issue in the form of ORM (Object Relational Mapping) tools in industry as developers use these tools during software development. This paper presents the performance evaluation of Java based ORM tools.
Shoaib Mahmood Bhatti   +2 more
doaj  

CoCryoViS: Collaborative online cryo‐electron tomography visualization system

open access: yesProtein Science, Volume 35, Issue 8, August 2026.
Abstract We present a collaborative, interactive, web‐based visualization and processing system for Cryo‐Electron Tomography (cryo‐ET) data that supports the complete workflow, from raw tilt‐series projections to final 3D segmentations. The system integrates tilt‐series alignment, motion correction, tomographic reconstruction, manual and pseudo ...
Omar Mena   +8 more
wiley   +1 more source

ЦИФРОВАЯ ТРАНСФОРМАЦИЯ ЭПИЗООТОЛОГИЧЕСКОГО МОНИТОРИНГА — ПРИМЕР УСПЕШНОГО ВНЕДРЕНИЯ

open access: yesCifra: Медико-биологические науки
Одной из важнейших задач эпидемиологического надзора в целом и эпизоотологического мониторинга в частности является прогнозирование эпидемического процесса, эпизоотий среди резервуарных хозяев, возможных вспышек среди населения как актуальных, так и ...
Беднарская Е.В.   +3 more
doaj   +1 more source

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