Results 131 to 140 of about 18,619 (303)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Layers of Nacre. [PDF]

J Grad Med Educ
Raukar NP.
europepmc   +1 more source

Protein Disulfide Isomerase Disassembles TDP‐43/G3BP1 Condensates and Antagonizes TDP‐43 Pathological Aggregates

Advanced Science, EarlyView.
Cytoplasmic aggregation of TDP‐43 is a common pathological feature in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer's disease with TDP‐43 pathology. This study reports that wild‐type PDI slows down phase separation of TDP‐43 through direct interaction with TDP‐43.
Jia‐Qi Liu, Hao Liu, Yu‐Xuan Sun, Yuying Li, Xiangyi Liu, Li‐Qiang Wang, Zhaofei Yang, Qi Fu, Xiaojiao Xu, Jie Chen, Yingshuang Zhang, Jun Zhou, Weidong Le, Mengchao Cui, Yi Liang   +14 more
wiley   +1 more source

Is Ornamentation a Universal Human Preference? Cross-Cultural and Developmental Evidence From Scotland, Pakistan, and Papua. [PDF]

Evol Psychol
Sorokowski P, Luty J, Jdryczka W, Stefanczyk MM.   +3 more
europepmc   +1 more source

Leaves from nature ornament. Plate 93, [engravings of designs depicting ivy leaves in full-size]

Engravings of designs depicting ivy leaves in full-size that are used as examples of designs depicting leaves in The Grammar of Ornament by Owen Jones. Illustrated by examples from various styles of ornament.Drawn on stone by F.
Bedford, Francis (1816-1894), Day & Son, Jones, Owen (1809-1874)   +2 more
core  

A Review on Catalytic Nanostructured Electrodes for Wearable and Implantable Abiotic Glucose Fuel Cells

Advanced Science, EarlyView.
This review identifies current and future directions in abiotic nanostructured catalysts to develop reliable and sustainable glucose fuel cells to power the next generation of bioelectronic devices. ABSTRACT The global rise in incidence of chronic diseases has led to the demand for innovative solutions that help patients manage their conditions with ...
Asghar Niyazi, Hannah S. Leese, Benjamin Metcalfe, Mirella Di Lorenzo   +3 more
wiley   +1 more source

Identity and mobility through personal ornaments in Upper Paleolithic cantabrian hunter-gatherer societies: Insights from Llonín cave (Asturias, Spain). [PDF]

PLoS One
Pérez-García de Los Salmones D, Cuenca-Solana D, González-Rabanal B, Marín-Arroyo AB, Duarte-Matías E, de la Rasilla-Vives M.   +5 more
europepmc   +1 more source

Leaves from nature ornament. Plate 92, [engravings of designs depicting vine leaves in full-size]

Engravings of designs depicting vine leaves in full-size that are used as examples of designs depicting leaves in The Grammar of Ornament by Owen Jones. Illustrated by examples from various styles of ornament.Drawn on stone by F.
Bedford, Francis (1816-1894), Day & Son, Jones, Owen (1809-1874)   +2 more
core  

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

Urbanization enhances ornament expression in a common waterbird. [PDF]

Behav Ecol
Chyb A, Włodarczyk R, Jedlikowski J, Minias P.   +3 more
europepmc   +1 more source