Results 151 to 160 of about 86,084 (265)

NR4A2-driven metabolic reprogramming in the heart: from adaptive response to maladaptive remodeling. [PDF]

Physiol Genomics
Stujanna EN, Yoshioka J.
europepmc   +1 more source

MicroRNAs as potential architects of immune dysregulation and megakaryocytic failure in immune thrombocytopenia

British Journal of Haematology, EarlyView.
Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu, Johan Rebetz, Lamya Garabet, Waleed Ghanima, Peipei Xu, Hans Wadenvik, Drew Provan, Rick Kapur, John W. Semple   +8 more
wiley   +1 more source

Synthetic Training Enables Deployment on Raw Drone Data: An Attention-Based Framework for Detecting Orphan Wells. [PDF]

Sensors (Basel)
Marcato A, Colman R, Milazzo D, Guiltinan E, Ma Z, O'Malley D, Viswanathan H, E Santos J.   +7 more
europepmc   +1 more source

Outcome of treatment with trametinib in adults with histiocytic neoplasms in the United Kingdom

British Journal of Haematology, EarlyView.
Trametinib (MEK inhibitor) shows efficacy in refractory and high‐risk adult histiocytic neoplasms. At a median follow‐up of 21.4 months, the clinical response rate was 81% (30/37) and the radiological response was 68% (25/37) (n = 37).
Rodothea Amerikanou, Talha Munir, Kristian Bowles, Christopher McNamara, Nikesh Chavda, Elizabeth Price, Jagdish Adiyodi, Alasdair Coles, Philippa Kelsey, Jeffery Smith, Richard Adams, Hayder Hussein, Rui Zhao, Trung Nguyen, Matthew Collin, Satyen Gohil   +15 more
wiley   +1 more source

The Italian Assessment System for Innovative Medicines: An 8-Year Retrospective Analysis of Outcomes, Criteria, Timelines and Funding Dynamics. [PDF]

Appl Health Econ Health Policy
Martellone L, Servidio C, Vaccaro M, Malandrini K, Coluccia A, Oliva A, Mastroianni CM, Polito G.   +7 more
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Candidate orphan genes: Reassessing uniqueness. [PDF]

PLoS One
Maan SK, Butzin XY, Ge SX, Butzin NC.
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Advances in orphan drug development for alpha-1 antitrypsin deficiency: a 2025 update from the FDA and EMA. [PDF]

Ther Adv Respir Dis
Höger P, Ries M, Olivares Rivera A, Ersöz H, Buschulte K, Fähndrich S, Kontogianni K, Herth F, Trudzinski FC.   +8 more
europepmc   +1 more source

Under the radar: a longitudinal exploration of mental health among children and adolescents experiencing parental and caregiver death during the COVID‐19 pandemic in South Africa

Child and Adolescent Mental Health, EarlyView.
Background Death of a caregiver during childhood can have profound influences on child wellbeing and later trajectories. Globally, child and adolescent mental health is an increasing area of concern with widespread negative implications. These data provide the first comprehensive exploration of the mental health of children experiencing COVID‐19 ...
Kathryn Steventon Roberts, Christina A. Laurenzi, Tatenda Mawoyo, Stefani Du Toit, Mark Tomlinson, Lucie Cluver, Lorraine Sherr   +6 more
wiley   +1 more source