Results 131 to 140 of about 5,265,871 (311)

Update in collecting duct carcinoma: Current aspects of the clinical and molecular characterization of an orphan disease. [PDF]

Front Oncol, 2022
Suarez C, Marmolejo D, Valdivia A, Morales-Barrera R, Gonzalez M, Mateo J, Semidey ME, Lorente D, Trilla E, Carles J.   +9 more
europepmc   +1 more source

HOA Interview, Group, Holiday Inn, Lauderdale by the Sea (Box 90, Folder 3)

, 1987
Series VIII: Audiocassettes features informal oral histories about the Hebrew Orphan Asylum and its alumni.Digital recordingDigital finding ...
Hebrew Orphan Asylum of New York
core  

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia

Cell Reports
Summary: While ATM loss of function has long been identified as the genetic cause of ataxia-telangiectasia (A-T), how it leads to selective and progressive degeneration of cerebellar Purkinje and granule neurons remains unclear.
Jenny Lai, Didem Demirbas, Junho Kim, Ailsa M. Jeffries, Allie Tolles, Junseok Park, Thomas W. Chittenden, Patrick G. Buckley, Timothy W. Yu, Michael A. Lodato, Eunjung Alice Lee   +10 more
doaj   +1 more source

Commentary: Pseudoxanthoma elasticum: An orphan disease with important implications for cardiothoracic surgeons. [PDF]

JTCVS Tech, 2021
Gottardi R.
europepmc   +1 more source

Rosenfeld, Bernard (Box 91, Folder 9)

, 1976
Series VIII: Audiocassettes features informal oral histories about the Hebrew Orphan Asylum and its alumni.Digital recordingDigital finding ...
Hebrew Orphan Asylum of New York
core  

Label‐Free YaxAB Nanopore Fingerprinting of Cancer‐Associated Single‐Residue Bcl‐xL Variants

Small Methods, EarlyView.
A YaxAB nanopore workflow enables label‐free single‐molecule fingerprinting of Bcl‐xL variants. Combined normalized current blockade and noise features generated reproducible current fingerprints for wild‐type Bcl‐xL and the cancer‐associated N136K and R165W variants across independent pores, with WT and N136K remaining distinct despite a mass ...
Minji Chung, Sohee Oh, Jin‐Sik Kim, Sungbo Hwang, Ki‐Baek Jeong, Seung‐Wook Chi   +5 more
wiley   +1 more source

HOA Interview, Bahia Mar, Ft. Lauderdale, Florida (Box 90, Folder 1)

, 1987
Series VIII: Audiocassettes features informal oral histories about the Hebrew Orphan Asylum and its alumni.Digital recordingDigital finding ...
Hebrew Orphan Asylum of New York
core  

Historical Development of Zoo Tapir (Tapirus ssp.) Survivorship

Zoo Biology, EarlyView.
The survivorship of tapirs in zoos has improved significantly over historical time. ABSTRACT Tapirs (Tapirus spp.) are large, long‐lived herbivores native to Central and South America and Southeast Asia. All species are currently classified as Vulnerable (T. terrestris) or Endangered (other species) in the IUCN SSC Red List.
Johanna E. Wittenberg, Laurie Bingaman Lackey, Jörg Beckmann, Marco Roller, Dennis W. H. Müller, Jan Pluháček, Marcus Clauss, João Pedro Meireles   +7 more
wiley   +1 more source

Exploring orphan GPCRs in neurodegenerative diseases

Frontiers in Pharmacology
Neurodegenerative disorders represent a significant and growing health burden worldwide. Unfortunately, limited therapeutic options are currently available despite ongoing efforts.
Devrim Öz-Arslan, Devrim Öz-Arslan, Melis Yavuz, Melis Yavuz, Beki Kan, Beki Kan   +5 more
doaj   +1 more source