Results 91 to 100 of about 3,868,024 (353)
Global Functional Atlas of \u3cem\u3eEscherichia coli\u3c/em\u3e Encompassing Previously Uncharacterized Proteins [PDF]
, 2009 One-third of the 4,225 protein-coding genes of Escherichia coli K-12 remain functionally unannotated (orphans). Many map to distant clades such as Archaea, suggesting involvement in basic prokaryotic traits, whereas others appear restricted to E.
Ali, Mehrab +20 more
core +1 more source
T-type Ca2+ Channels: T for Targetable [PDF]
, 2018 In the last decade TTCC have been unveiled as key regulators of cancer cells biology and thus have been proposed as chemotherapeutic targets. Indeed in vitro and in vivo studies indicate that TTCC pharmacological blockers have a negative impact on the ...
Cantí Nicolás, Carles +5 more
core +2 more sources
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims In the context of pharmacology and toxicology education, there is a growing shift toward programmatic assessment models that prioritize longitudinal learning, reflection and development of higher‐order cognitive skills. As part of this transition, we are exploring alternative and more meaningful forms of assessment. This qualitative study
Narin Akrawi +2 more
wiley +1 more source
Orphan drugs : future viability of current forecasting models, in light of impending changes to influential market factors [PDF]
, 2011 Thesis (S.M.)--Harvard-MIT Division of Health Sciences and Technology, 2011.Cataloged from PDF version of thesis.Includes bibliographical references (p. 58-61).Interviews were conducted to establish a baseline for how orphan drug forecasting is currently
Gottlieb, Joshua
core
A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response [PDF]
, 2008 The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are closely related orphan nuclear hormone receptors that play a critical role as xenobiotic sensors in mammals.
Anja Rode +19 more
core +3 more sources
Cancers, 2018 A better understanding of mechanistic insights into genes and enzymes implicated in rare diseases provide a unique opportunity for orphan drug development. Advances made in identification of synthetic lethal relationships between rare disorder genes with
S. Bhattacharjee, Saikat Nandi
semanticscholar +1 more source
Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor
Cancer Communications, EarlyView.Abstract Neutrophils are important components of the immune system and play a key role in defending against pathogenic infections and responding to inflammatory cues, including cancer. Their dysregulation indicates potential disease risk factors. However, their functional importance in disease progression has often been underestimated due to their ...
Wenpeng Cai +6 more
wiley +1 more source
Estimating the budget impact of orphan medicines in Europe: 2010 - 2020
Orphanet Journal of Rare Diseases, 2011 Background Orphan drugs are a growing issue of importance to European healthcare policy makers. The success of orphan drug legislation in Europe has resulted in an increasing number of licensed medicines for rare diseases, and many more yet unlicensed ...
Milanova Tsveta +2 more
doaj +1 more source
The Promise of Priority Review Vouchers as a Legislative Tool to Encourage Drugs for Neglected Diseases [PDF]
, 2013 Despite the intellectual property system’s success in promoting the economic well-being of the United States, this system has not achieved all socially valuable ends.
Hamming, Lesley
core +1 more source
Survey of Japanese Orphan Drug Program: Factors Related to Successful Marketing Approval
Journal of clinical pharmacology, 2019 The basic components of regulatory and supporting policies for orphan drug development appear similar between the United States and Japan, but drugs designated as orphan drugs have been different between the 2 countries.
Kenji Harada, Kazuki Toriyabe, S. Ono
semanticscholar +1 more source