Results 131 to 140 of about 3,868,024 (353)
Learning Health Systems, EarlyView.Abstract Objective Extracting and curating data from large clinical information systems is challenging, and the optimal methodology is often unclear. This review was to systematically investigate and appraise the research literature to assess existing methods used by healthcare organizations to extract data from the electronic medical record (EMR). The
Han Chang Lim +6 more
wiley +1 more source
Are payers treating orphan drugs differently?
Journal of Market Access & Health Policy, 2014 Background: Some orphan drugs can cost hundreds of thousands of dollars annually per patient. As a result, payer sensitivity to the cost of orphan drugs is rising, particularly in light of increased numbers of new launches in recent years.
Joshua P. Cohen, Abigail Felix
doaj +1 more source
Claudication as an ‘Orphan Disease’: Rationale and Goals of Drug Therapy for Peripheral Arterial Disease [PDF]
, 1996 Alan T. Hirsch
openalex +1 more source
$1 Billion drug deal creates debt for "tomorrow's AIDS orphans" [PDF]
, 2000 A. Ferriman
openalex +1 more source
Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats. [PDF]
, 2018 GPR139 is an orphan G protein-coupled receptor (GPCR) that is expressed mainly in the brain, with the highest expression in the medial habenula. The modulation of GPR139 receptor function has been hypothesized to be beneficial in the treatment of some ...
Conlisk, Dana +5 more
core
A comparative study of orphan drug prices in Europe
Journal of Market Access & Health Policy, 2017 Background and Objective: This study assessed price differences by comparing annual treatment costs of similarly available orphan drugs in France, Germany, Italy, Norway, Spain, Sweden, and UK.
K. E. Young +3 more
semanticscholar +1 more source
Recent Advancements in the Treatment of Age‐Related Macular Degeneration
Med Research, EarlyView.ABSTRACT Age‐related macular degeneration (AMD) is a prevalent cause of visual impairment and blindness among the elderly. AMD can be categorized into two subtypes: “wet” and “dry.” Current treatments for wet AMD mainly involve anti‐vascular endothelial growth factor (VEGF) drugs, and there are three U.S.
Shan Liu +10 more
wiley +1 more source
Development of chidamide for peripheral T-cell lymphoma, the first orphan drug approved in China.
Intractable & Rare Diseases Research, 2016 Peripheral T-cell lymphoma (PTCL) is a set of rare and highly heterogeneous group of mature T- and NK-cell neoplasms associated with poor outcomes and lack of standard and effective therapies.
Xianping Lu +4 more
semanticscholar +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar +4 more
wiley +1 more source
Patients with Gaucher disease display systemic oxidative stress dependent on therapy status
Molecular Genetics and Metabolism Reports, 2020 Gaucher disease is an autosomal recessive metabolic disorder caused by mutations in GBA1, which encodes for the lysosomal hydrolase enzyme, β-glucocerebrosidase.
Reena V. Kartha +9 more
doaj