Results 141 to 150 of about 3,868,024 (353)
Novel trends in orphan market drug discovery: amyotrophic lateral sclerosis as a case study [PDF]
, 2002 E. Clark Jennifer
openalex +1 more source
Exploring patient and family involvement in the lifecycle of an orphan drug: a scoping review
Orphanet Journal of Rare Diseases, 2017 BackgroundPatients and their families have become more active in healthcare systems and research. The value of patient involvement is particularly relevant in the area of rare diseases, where patients face delayed diagnoses and limited access to ...
Andrea Young +4 more
semanticscholar +1 more source
The Journal of Pathology, EarlyView.Abstract The diagnostic classification of differentiated thyroid cancer has been a longstanding topic of debate among pathologists, largely due to high interobserver variability. This complexity has increased with the expansion of tumor types and subtypes.
Sylvia L Asa +8 more
wiley +1 more source
Phytochemical Nanoparticles for the Treatment of Neurological Disorders
Phytochemical Analysis, EarlyView.ABSTRACT Neurological disorders impose a significant burden on the healthcare systems. The latest published data by WHO indicated that stroke was the second leading cause of death globally in 2020, with Alzheimer's disease (AD) and other dementias in the seventh position.
Touraj Ehtezazi, Satyajit D. Sarker
wiley +1 more source
Ethical issues in funding orphan drug research and development [PDF]
, 2005 Christian A. Gericke +2 more
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PLANTS, PEOPLE, PLANET, EarlyView.Future research and development of biological materials for foods, feeds, fibres, materials and medicines will increasingly rely on information and knowledge using Artificial Intelligence (AI) applications for detecting patterns to make useful decisions.
Charles Lawson +2 more
wiley +1 more source
Children in need of medical innovation [PDF]
Children are therapeutic orphans and an underprivileged group in innovations derived from drug therapy. As the innovation process of pharmaceuticals is a long, risky and very costly business, economists typically emphasise lack of profit incentives and ...
Entorf, Horst +2 more
core +3 more sources
Understanding Disease Heterogeneity and Patient Characteristics in Patients with Amyotrophic Lateral Sclerosis (ALS) [PDF]
, 2019 Background: Amytrophic lateral sclerosis (ALS) is a fatal neurologic disease that is projected to double in worldwide incidence in the next 20 years.
Mathew, Veena
core
State‐of‐the‐Art on Model‐Informed Drug Development Approaches for Pediatric Rare Diseases
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Pediatric rare diseases present unique challenges for drug development due to small patient populations, ethical constraints on clinical trial design, and limited prospectively defined natural history data. Model‐Informed Drug Development (MIDD) has emerged as a powerful paradigm to address these challenges by leveraging quantitative methods ...
Rajesh Krishna +4 more
wiley +1 more source