Transcriptional up-regulation of relaxin-3 by Nur77 attenuates β-adrenergic agonist-induced apoptosis in cardiomyocytes. [PDF]
, 2018 The relaxin family peptides have been shown to exert several beneficial effects on the heart, including anti-apoptosis, anti-fibrosis, and anti-hypertrophy activity.
Cheng, Fang +10 more
core +1 more source
Deletion of Gpr27 in vivo reduces insulin mRNA but does not result in diabetes. [PDF]
, 2020 Gpr27 is a highly conserved, orphan G protein coupled receptor (GPCR) previously implicated in pancreatic beta cell insulin transcription and glucose-stimulated insulin secretion in vitro. Here, we characterize a whole-body mouse knockout of Gpr27. Gpr27
Chopra, Deeksha G +4 more
core
Policy Effectiveness in Managing Drug Shortages: Evidence From South Korea (2015–2024)
World Medical &Health Policy, EarlyView.ABSTRACT Drug shortages represent a growing policy challenge for healthcare systems worldwide. This study investigates actual drug shortage events in South Korea from 2015 to 2024, using a “Shortage Occurred vs. Shortage Non‐Occurred” framework to distinguish real‐world disruptions from administrative classifications.
Seung‐Rae Yu
wiley +1 more source
BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.ABSTRACT Objective Foetal growth restriction (FGR) affects 10% of pregnancies, contributing to 30% of stillbirths. Current management of early‐onset FGR (< 32 + 0 weeks' gestation) delivers the foetus before stillbirth or irreversible organ damage. The resulting preterm births create additional risks independent of FGR.
George Bray +20 more
wiley +1 more source
Is the current approach to reviewing new drugs condemning the victims of rare diseases to death? A call for a national orphan drug review policy [PDF]
, 2006 J. T. R. Clarke
openalex +1 more source
Drugs for exceptionally rare diseases: a commentary on Hughes et al [PDF]
Recently in this journal, Hughes and colleagues discussed special funding status to ultra-orphan drugs. They concluded that there should be a uniform policy for the provision of orphan drugs across Europe; that complete restriction was impractical, and ...
Claxton, K. +3 more
core
Is Twenty-two Months Beyond the Best Interest of the Child? ASFA\u27s Guidelines for the Termination of Parental Rights [PDF]
, 2001 This Note first discusses the legal precedents, child development theories, and policies regarding reasonable efforts and parental termination that led to the enactment of ASFA.
Hort, Katherine A.
core +1 more source
Annals of Applied Biology, EarlyView.Triticale and lupin are promising candidates for sustainable intercropping in low‐input, mixed crop–livestock farming systems in the Mediterranean basin, where they can be grown as rain‐fed crops during the autumn‐winter period. A field trial conducted in Sardinia demonstrated several key findings: the slower canopy development and shorter stature of ...
Rosella Motzo, Francesco Giunta
wiley +1 more source
Development of “orphan drugs” in Europe is too slow [PDF]
, 2006 Roger Dobson
openalex +1 more source
Early Levodopa Therapy in Tyrosine Hydroxylase Deficiency
Movement Disorders Clinical Practice, EarlyView.
Claudio M. de Gusmao +4 more
wiley +1 more source