Results 161 to 170 of about 3,868,024 (353)

Langerhans Cell Modulation in Atopic Dermatitis Is TLR2/SOCS1‐Dependent and JAK Inhibitor‐Sensitive

Allergy, EarlyView.
Constitutive exposure to TLR2 ligands can modify Langerhans cell (LC) activation capacity and outcome, being similar to LC in atopic dermatitis skin. While maturation marker and migration are impaired, the cytokine profile switches and favors atopic dermatitis‐related IL‐1β and IL‐18.
Yuxuan Deng, Nicole Leib, Sylvia Schnautz, Said Benfadal, Johannes Oldenburg, Thomas Bieber, Nadine Herrmann   +6 more
wiley   +1 more source

Orphan drugs [PDF]

Nature, 1992
openaire   +2 more sources

Adenylosuccinic Acid: An Orphan Drug with Untapped Potential. [PDF]

Pharmaceuticals (Basel), 2023
Rybalka E, Kourakis S, Bonsett CA, Moghadaszadeh B, Beggs AH, Timpani CA.   +5 more
europepmc   +1 more source

Predictors of orphan drug approval in the European Union [PDF]

, 2008
Harald E. Heemstra, Remco L. de Vrueh, Sonja van Weely, Hans A. Büller, Hubert G. M. Leufkens   +4 more
openalex   +1 more source

Orphan drugs

Arbor: Ciencia, Pensamiento y Cultura, 2018
Orphan drugs are intended for the treatment of diseases of low prevalence, also known as rare diseases. Research and development into new therapies for this heterogeneous group of diseases presents a number of well-recognized difficulties. One of these is that the small number of patients affected jeopardizes the economic return on the investment made ...
Fontanet Sacristán, Juan Manuel, Torrent-Farnell, Josep   +1 more
openaire   +1 more source

Bradycardia and Other Arrhythmias in Patients With Hepatorenal Syndrome‐Acute Kidney Injury Following Terlipressin Treatment: A Pooled Analysis of Three North American Phase III Clinical Studies

Alimentary Pharmacology &Therapeutics, EarlyView.
In a pooled analysis, bradycardia was observed in 6% of terlipressin‐treated patients but rarely required a dose interruption or reduction. Arrhythmia serious adverse event incidences were low and similar in both treatment groups. Routine intensive cardiac monitoring for the detection of arrhythmias may not be necessary during terlipressin ...
Jasmohan S. Bajaj, Paul Kwo, Stephen Chris Pappas, Jacqueline G. O'Leary, Khurram Jamil, Sanaz Cardoza, Florence Wong   +6 more
wiley   +1 more source

How to START? Four pillars to optimally begin your orphan drug development. [PDF]

Orphanet J Rare Dis, 2023
Jonker AH, Batista L, Gabaldo M, Hivert V, Ardigo D, IRDiRC ODDG TF and IRDiRC TSC.   +5 more
europepmc   +1 more source

Anaplastic large cell lymphoma in children and adolescents

British Journal of Haematology, EarlyView.
Summary Anaplastic lymphoma kinase (ALK)‐positive anaplastic large‐cell lymphoma (ALCL) accounts for >95% of ALCL cases in children and adolescents. The first description of ALCL as a CD30‐positive lymphoma in 1985 was followed by the detection of chromosomal translocations involving the ALK gene at chromosome 2p23.
Eric J. Lowe, Wilhelm Woessmann
wiley   +1 more source

Cardiotoxicity in patients with acute myeloid leukaemia following anthracycline‐containing chemotherapy: A population‐based matched cohort study

British Journal of Haematology, EarlyView.
Summary Anthracycline‐containing chemotherapy is associated with cardiovascular diseases (CVDs). While knowledge regarding the extent of cardiotoxicity in adult patients with acute myeloid leukaemia (AML) is sparse, anthracyclines remain a key component in the treatment.
Rikke Hedegaard Jensen, Christian Teglgaard, Jonas Faartoft Jensen, Joachim Baech, Claus Werenberg Marcher, Anne Stidsholt Roug, Andreas Due Ørskov, Claudia Schöllkopf, Daniel Tuyet Kristensen, Rasmus Froberg Brøndum, Marianne Tang Severinsen   +10 more
wiley   +1 more source

Using Artificial Intelligence to Advance the Research and Development of Orphan Drugs

Businesses
While artificial intelligence has successful and innovative applications in common medicine, could its application facilitate research on rare diseases? This study explores the application of artificial intelligence (AI) in orphan drug research, focusing
Carla Irissarry, Thierry Burger-Helmchen
doaj   +1 more source