Results 271 to 280 of about 3,868,024 (353)

New opportunity for orphan drug development in Japan: Early exploratory clinical trial bases promote drug translation from basic studies to clinical application

, 2012
Song
openalex   +2 more sources

Orphan Drugs and Orphan Tests in the USA

Public Health Genomics, 2004
openaire   +3 more sources

Mono and combination therapies in pulmonary arterial hypertension patients with comorbidities: A COMPERA analysis

ESC Heart Failure, Volume 12, Issue 4, Page 2726-2735, August 2025.
AIM This analysis provides a comparison of the efficacy of initial mono and combination therapy in patients with PAH and cardiovascular comorbidities or with risk factors of HFpEF (heart failure with preserved ejection fractioin).METHOD Data from the European COMPERA registry were used for a matched pair analysis.
Dirk Skowasch, Christine Pausch, Doerte Huscher, David Pittrow, Judith Wede, Fabian Kreimendahl, Stephan Rosenkranz, Stephan Beckmann, Matthias Held, Ekkehard Grünig, H. Ardeschir Ghofrani, Hans Klose, Andris Skride, Michael Halank, Stefan Stadler, Marion Delcroix, Anton Vonk‐Noordegraaf, Ralf Ewert, Grzegorz Kopec, Marius M. Hoeper, Karen M. Olsson   +20 more
wiley   +1 more source

Prescription of guideline‐directed medical therapy in heart failure: impact on mortality and readmission

ESC Heart Failure, Volume 12, Issue 4, Page 2791-2802, August 2025.
Routine data analysis showing a better outcome regarding mortality and readmission in HF patients when being prescribed the current four‐drug treatment (vs. the outdated two‐drug therapy) 91–365 days after index hospital stay. Abstract Aims The 2021 European heart failure (HF) guidelines recommend the combination of four drugs as a standard therapy ...
Martin Möckel, Samipa Pudasaini, Kristina Feldmann, Henning Thomas Baberg, Benny Levenson, Jürgen Malzahn, Thomas Mansky, Guido Michels, Christian Günster, Elke Jeschke   +9 more
wiley   +1 more source

Financing drug discovery for orphan diseases

, 2013
David E. Fagnan, Austin A. Gromatzky, Roger M. Stein, Jose-Maria Fernandez, Andrew W. Lo   +4 more
openalex   +1 more source

Dilated cardiomyopathy evaluation with Imagenomics: combining multimodal cardiovascular imaging and genetics

ESC Heart Failure, Volume 12, Issue 4, Page 2669-2690, August 2025.
Systematic approach to dilated cardiomyopathy diagnosis. Dilated cardiomyopathy is a clinical diagnosis characterized by the presence of left ventricular dilatation and systolic disfunction unexplained by abnormal loading conditions or coronary artery disease.
Kristian Galanti, Ghaith Sharaf Dabbagh, Fabrizio Ricci, Sabina Gallina, Roberta Giansante, Ron Jacob, Edmond Obeng‐Gyimah, Leslie T. Cooper Jr, Sanjay K. Prasad, David H. Birnie, Andrew P. Landstrom, Selma F. Mohammed, Saidi Mohiddin, Mohammed Y. Khanji, Anwar A. Chahal   +14 more
wiley   +1 more source

Generation of Regulatory T Cells From Human Memory CD4+T Cells by Upregulation of Naked Cuticle Homolog 2

European Journal of Immunology, Volume 55, Issue 8, August 2025.
This study discovered the small molecule 9‐methoxy‐6‐methylindolo[3,2‐b] quinoxaline (IFA005) as a potent immunomodulator capable of converting human memory CD4⁺ T cells into functional Foxp3⁺ regulatory T cells. IFA005 suppresses Th2 cytokines (IL‐4, IL‐5, and IL‐13) and promotes the iTreg phenotype by inhibiting Wnt/β‐catenin signaling through NKD2 ...
Jiajun He, Kristy Ou, Michael Schmueck‐Henneresse, Edgar Specker, Jérôme Paul, Marc Nazare, Jens Peter von Kries, Julia K. Polansky, Alf Hamann, Stefan Frischbutter   +9 more
wiley   +1 more source

Effect of Aspirin Challenge on Innate Lymphoid Cells in Asthma Patients With Aspirin Hypersensitivity

European Journal of Immunology, Volume 55, Issue 8, August 2025.
In N‐ERD patients, oral aspirin‐induced bronchospasm is associated with increased blood group 1 innate lymphoid cells (ILC1s), decreased sputum eicosanoids, and increased urinary leukotriene E4 (LTE4), suggesting a potential role of blood ILC1s in aspirin‐induced bronchoconstriction. ABSTRACT Previous studies confirmed increased group 2 innate lymphoid
Radosław Kacorzyk, Bogdan Jakiela, Alicja Maciejska, Agnieszka S. Węgrzyn, Adam Ćmiel, Marek Sanak, Lucyna Mastalerz   +6 more
wiley   +1 more source

The Role of Interleukin‐23 and Interleukin‐17 in Peri‐Implant Crevicular Fluid of Subjects With Peri‐Implant Disease: A Systematic Review

Journal of Clinical Laboratory Analysis, Volume 39, Issue 15, August 2025.
The role of IL‐23/IL‐17 cytokine axis in peri‐implant disease. ABSTRACT Background Activation of the IL‐23/IL‐17 cytokine axis could trigger peri‐implant bone loss. The aim of this review was to analyze whether in people with peri‐implantitis (PI) and peri‐implant mucositis (PM) the concentrations of the interleukin‐23 and interleukin‐17 in peri ...
Mario Alberto Alarcón‐Sánchez, Julieta Sarai Becerra‐Ruiz, Ruth Rodríguez‐Montaño, Sarah Monserrat Lomelí‐Martínez, Lilibeth‐Stephania Escoto‐Vasquez, Artak Heboyan   +5 more
wiley   +1 more source

Trends In Orphan Drug Spending And Out-Of-Pocket Spending Among US Children, 2013-18. [PDF]

Health Aff (Millwood), 2020
Chua KP, Conti RM.
europepmc   +1 more source