Results 301 to 310 of about 3,868,024 (353)

Enhancing Rare Disease Awareness and Education Among Medical Professionals and Students in Türkiye

open access: yesJournal of Evaluation in Clinical Practice, Volume 31, Issue 5, August 2025.
ABSTRACT Purpose Rare diseases (RDs), which are often chronic, degenerative, and life‐threatening conditions, pose significant challenges due to their complexity and limited awareness among healthcare professionals. This study assessed the knowledge, awareness, and educational needs related to RDs among 5th‐ and 6th‐year medical students at Atatürk ...
Öznur Karagöz   +8 more
wiley   +1 more source

Plant‐derived vesicle‐like nanoparticles in food crops: emerging insights into nutritional biofortification and biomedical applications

open access: yesPlant Biotechnology Journal, Volume 23, Issue 8, Page 3260-3282, August 2025.
Summary Food crops, as the cornerstone of human nutrition, not only provide essential macronutrients but also encompass a rich spectrum of bioactive compounds that promote health. Of particular significance are underutilized minor crops, which contain unique beneficial components with proven nutraceutical properties. These valuable bioactive components
Jie Wang, Zhaosheng Kong
wiley   +1 more source

Integrated Disease Management, Adaptation and Genomics of Fungal Plant Pathogens in Cropping Systems

open access: yesPlant Pathology, Volume 74, Issue 6, Page 1445-1469, August 2025.
Knowledge of the fungal genome and multifaceted evolutionary forces need to be considered together in understanding and managing agricultural plant pathogen adaptation relative to integrated disease management (IDM) strategies. ABSTRACT Crop production systems contribute significantly to maintaining global food security. These systems often involve the
Hayley Wilson   +5 more
wiley   +1 more source

Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology

open access: yesCA: A Cancer Journal for Clinicians, Volume 75, Issue 4, Page 282-307, July/August 2025.
Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari   +7 more
wiley   +1 more source

Nuclear Receptor ERRγ Protects Against Cardiac Ischemic Injury by Suppressing GBP5‐Mediated Myocardial Inflammation

open access: yesThe FASEB Journal, Volume 39, Issue 14, 31 July 2025.
Cardiomyocyte‐specific overexpression of ERRγ after myocardial infarction improves cardiac function by suppressing the expression of its pro‐inflammatory downstream target GBP5, thereby inhibiting inflammasome assembly, alleviating myocardial inflammation, and pyroptosis.
Junhao Qiu   +12 more
wiley   +1 more source

Novel Para‐Phenylenediamine‐Based Derivatives as Receptor Tyrosine Kinase‐like Orphan Receptor 1 (ROR1) Inhibitors: An In Vitro Preliminary Characterization

open access: yesChemMedChem, Volume 20, Issue 14, July 18, 2025.
ROR1 represents a promising target for the development of novel antiproliferative compounds, giving its high expression in different cancer cell lines. The present study describes the workflow leading to the design, synthesis, and characterization of a series of para‐phenylenediamine‐based compounds able to interact with the target kinase, inhibiting ...
Gerardina Smaldone   +17 more
wiley   +1 more source

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