Results 81 to 90 of about 109,656 (184)
BJPsych OpenBackground Non-suicidal self-injury (NSSI) often emerges during adolescence and young adulthood. A prior open-label pilot study suggested that N-acetylcysteine (NAC) may reduce NSSI frequency in young individuals.
Victoria Papke +11 more
doaj +1 more source
Transcriptional up-regulation of relaxin-3 by Nur77 attenuates β-adrenergic agonist-induced apoptosis in cardiomyocytes. [PDF]
, 2018 The relaxin family peptides have been shown to exert several beneficial effects on the heart, including anti-apoptosis, anti-fibrosis, and anti-hypertrophy activity.
Cheng, Fang +10 more
core +1 more source
Is Twenty-two Months Beyond the Best Interest of the Child? ASFA\u27s Guidelines for the Termination of Parental Rights [PDF]
, 2001 This Note first discusses the legal precedents, child development theories, and policies regarding reasonable efforts and parental termination that led to the enactment of ASFA.
Hort, Katherine A.
core +1 more source
Drugs for exceptionally rare diseases: a commentary on Hughes et al [PDF]
Recently in this journal, Hughes and colleagues discussed special funding status to ultra-orphan drugs. They concluded that there should be a uniform policy for the provision of orphan drugs across Europe; that complete restriction was impractical, and ...
Claxton, K. +3 more
core
Regulating Innovative Medicine: Fitting Square Pegs in Round Holes [PDF]
, 2005 Increasingly, innovative medical products are creating a quandary for the Food and Drug Administration ( FDA ) because they often transcend the FDA\u27s traditional categorical approach to regulating medical products. In a recent attempt to simplify this
Lavender, Mark
core +1 more source
The hope for neglected diseases: R&D incentives [PDF]
Neglected diseases are neglected because they cannot generate enough return on R&D to pharmaceutical firms. This paper analyzes and compares existing proposals for public intervention in R&D for neglected diseases.
Brigitte Granville, Eshref Trushin
core
Book Review: Deforming Tort Reform [PDF]
, 1990 The storms buffeting the tort system over the past two decades have come in three distinct waves. In the late 1960s, steep increases in the insurance costs incurred by health care providers protecting against negligence claims by patients triggered what ...
Page, Joseph A.
core +1 more source
Children in need of medical innovation [PDF]
Children are therapeutic orphans and an underprivileged group in innovations derived from drug therapy. As the innovation process of pharmaceuticals is a long, risky and very costly business, economists typically emphasise lack of profit incentives and ...
Entorf, Horst +2 more
core
Regulating Rare Disease: Safely Facilitating Access to Orphan Drugs [PDF]
, 2018 While approximately one in ten Americans suffers from a rare disease, only 5 percent of rare diseases have a U.S. Food and Drug Administration (FDA) approved treatment.
Bannister, Julien B.
core +1 more source
Arbor: Ciencia, Pensamiento y Cultura, 2018 Orphan drugs are intended for the treatment of diseases of low prevalence, also known as rare diseases. Research and development into new therapies for this heterogeneous group of diseases presents a number of well-recognized difficulties. One of these is that the small number of patients affected jeopardizes the economic return on the investment made ...
Fontanet Sacristán, Juan Manuel +1 more
openaire +1 more source