Results 71 to 80 of about 68,610 (290)

Rhodopsin orphan GPCR20 interacts with neuropeptides and directs growth, sexual differentiation, and egg production in female Schistosoma mansoni

Microbiology Spectrum
Schistosomes are parasitic flatworms that cause schistosomiasis, a neglected tropical disease of worldwide importance. Since standard treatment of schistosomiasis relies on a single drug, praziquantel, alternative drugs are needed.
Xuesong Li, Oliver Weth, Martin Haimann, Max F. Möscheid, Theresa S. Huber, Christoph G. Grevelding   +5 more
doaj   +1 more source

Wnt5a induces ROR1 to complex with HS1 to enhance migration of chronic lymphocytic leukemia cells. [PDF]

, 2017
ROR1 (receptor tyrosine kinase-like orphan receptor 1) is a conserved, oncoembryonic surface antigen expressed in chronic lymphocytic leukemia (CLL).
A Butrym, A Stacchini, AH Daneshmanesh, AM Brunati, B Cui, C Scielzo, C Scielzo, C Wilson, D Kitamura, DA Dehring, E Roszmusz, E Ten Hacken, E ten Hacken, ES Witze, F Frezzato, GF Widhopf II, HE Broome, J Skokowa, J Yu, J Yu, JA Burger, JA Di Paolo, JJ Hao, K Alexandropoulos, K Kurokawa, M Lettau, M Muzio, M Rodriguez-Niedenfuhr, MY Choi, N Martinez-Quiles, P Masiakowski, P Masiakowski, PJ Cavnar, S Baskar, S Mukherjee, T Fukuda, T Uruno, TS Gomez, WC Forrester, WC Forrester, X Qi, Y Suzuki, Y Takemoto, Y Yamanashi, YK Xu, Z Weng   +45 more
core   +1 more source

From cramming to binge‐watching: Integrating documentary‐based assessment into a pharmacology and toxicology curriculum—a qualitative study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims In the context of pharmacology and toxicology education, there is a growing shift toward programmatic assessment models that prioritize longitudinal learning, reflection and development of higher‐order cognitive skills. As part of this transition, we are exploring alternative and more meaningful forms of assessment. This qualitative study
Narin Akrawi, Heleen van der Sijs, Floor van Rosse   +2 more
wiley   +1 more source

Children in need of medical innovation [PDF]

Children are therapeutic orphans and an underprivileged group in innovations derived from drug therapy. As the innovation process of pharmaceuticals is a long, risky and very costly business, economists typically emphasise lack of profit incentives and ...
Entorf, Horst, Fegert, Jörg, Kölch, Michael   +2 more
core   +3 more sources

Race, Money and Medicines [PDF]

, 2006
Taking notice of race is both risky and inevitable, in medicine no less than in other endeavors. The literature on race as a classifying tool in clinical research poses this core dilemma: On the one hand, race can be a useful stand-in for unstudied ...
Bloche, Maxwell Gregg
core   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Advance price or purchase commitments to create markets for treatments for diseases of poverty: lessons from three policies

Bulletin of the World Health Organization, 2005
New drugs and vaccines are needed for tackling diseases of poverty in low- and middle-income countries. The lack of effective demand or market for these products translates into insufficient investment being made in research and development to meet the ...
Towse Adrian, Kettler Hannah
doaj  

Promoting Academic Entrepreneurship in Europe and the United States: Creating an Intellectual Property Regime to Facilitate the Efficient Transfer of Knowledge from the Lab to the Patient [PDF]

, 2015
In 2014, the European Commission announced the launch of a study of knowledge transfer by public research organizations and other institutes of higher learning “to determine which additional measures might be needed to ensure an optimal flow of knowledge
Bagley, Constance E., Tvarnø, Christina D.   +1 more
core   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. [PDF]

, 2016
The androgen receptor (AR) is overexpressed and hyperactivated in human castration-resistant prostate cancer (CRPC). However, the determinants of AR overexpression in CRPC are poorly defined.
Borowsky, Alexander D, Cai, Demin, Chen, Hong-Wu, Duan, Zhijian, Evans, Christopher P, Evans, Ronald M, Gao, Allen C, Kung, Hsing-Jien, Lam, Kit S, Louie, Maggie C, Wang, Junjian, Xiang, Qiuping, Xu, Jianzhen, Xu, Yong, Xue, Xiaoqian, Yang, Joy C, Zhang, Yan, Zou, June X   +17 more
core   +2 more sources