How to Imagine Educational AI: The Filling of a Pail or the Lighting of a Fire?
Educational Theory, EarlyView.Abstract Recent advances in artificial intelligence (e.g., machine learning, generative AI) have led to increased interest in its application in educational settings. AI companies hope to revolutionize teaching and learning by tailoring material to the individual needs of students, automating parts of teachers' jobs, or analyzing educational data to ...
Michał Wieczorek, Alberto Romele
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Drug lag and associated factors of orphan drugs approved by the U.S. in China. [PDF]
Front PharmacolMo Q, He J, Guo Q, Yang Y.
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Comparison of US and EU Prices for Orphan Drugs in the Perspective of the Considered US Orphan Drugs Act Modifications and Discussed Price-Regulation Mechanisms Adjustments in US and European Union. [PDF]
Int J Environ Res Public Health, 2022 Żelewski P +16 more
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European Journal of Haematology, EarlyView.ABSTRACT Objective This systematic review and meta‐analysis aimed to evaluate the risk of thromboembolic events and assess the overall safety and effectiveness of avatrombopag in adult patients with immune thrombocytopenia using real‐world evidence. Methods A systematic search was conducted following the PRISMA 2020 guidelines.
M. L. Lozano, D. Valcarcel
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Can the Development of Orphan Drugs Include Wider Patient Engagement? A Citizens' Jury to Explore a Promissory Notion. [PDF]
Health ExpectFrost J +5 more
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Current status and trend of clinical development of orphan drugs in China. [PDF]
Orphanet J Rare Dis, 2022 Xiang Z +4 more
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Equine Veterinary Education, EarlyView.Summary Gastric outflow obstruction (GOO) occasionally requires surgical intervention in foals when medical management fails. Current literature lacks consensus on several surgical decisions, with most comprehensive reports dating back over a decade. Critical aspects—including jejunal loop orientation and necessity of jejunojejunostomy—remain debated ...
P. Fernández Hernández +8 more
wiley +1 more source
Methodological challenges in Dutch HTA of non-oncological orphan drugs: a retrospective analysis and price comparison using different pricing models. [PDF]
Orphanet J Rare DisWalraven J, Kaveh M, Uyl-de Groot C.
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Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression
The FEBS Journal, EarlyView.T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera +5 more
wiley +1 more source