Results 211 to 220 of about 88,273 (287)
Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone +1 more
wiley +1 more source
The 340B Program: A Federal Program in Desperate Need of Revision After Two-And-A-Half Decades of Uncertainty [PDF]
Fisher, Nicholas C.
core +1 more source
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley +1 more source
Opportunities and challenges in protein structure prediction
Abstract Deep learning methods, particularly exemplified by AlphaFold2, have revolutionized the field of protein structure prediction—an achievement recognized by the 2024 Nobel Prize in Chemistry awarded to its core developers. Despite this remarkable achievement, the broader protein folding problem is far from solved. Key challenges—each representing
Wenkai Wang +3 more
wiley +1 more source
Development of orphan drugs for rare diseases. [PDF]
Yoo HW.
europepmc +1 more source
ABSTRACT This article examines the historical displacement of Indigenous peoples in Venezuela, focusing on the links between indigenist policies and the exploitation of natural resources, particularly oil, throughout the 20th century. Using a combined historical and ethnographic approach, it demonstrates how the formation of the Venezuelan nation‐state
Gabriel Tardelli
wiley +1 more source
ABSTRACT Globally, millions of children are adopted or placed in alternative care settings (i.e., residential, foster, or kinship care). The current study explores the factors leading to separation from parents and adoption or placement in alternative care by investigating orphanhood status, perceived antecedents to placement, types of alternative care
Nicole Gilbertson Wilke +2 more
wiley +1 more source
Clinical aspects of reimbursement policies for orphan drugs in Central and Eastern European countries. [PDF]
Jakubowski S +13 more
europepmc +1 more source
ABSTRACT Objectives The WIL‐31 study demonstrated efficacy and safety of prophylaxis with the plasma‐derived von Willebrand factor/factor VIII concentrate wilate in von Willebrand disease (VWD) of all types and was the only prospective study with an on‐demand run‐in study as an intra‐individual comparator.
Claudia Djambas Khayat +10 more
wiley +1 more source
Issues, Challenges and Opportunities for Economic Evaluations of Orphan Drugs in Rare Diseases: An Umbrella Review. [PDF]
Grand TS +5 more
europepmc +1 more source

