Results 221 to 230 of about 88,754 (289)
The Journal of Physiology, EarlyView.Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley +1 more source
Therapeutic Value of Orphan Drugs Approved by Health Canada: A Cross-Sectional Study. [PDF]
J Gen Intern MedLexchin J.
europepmc +1 more source
Rapid Communications in Mass Spectrometry, Volume 40, Issue 8, 30 April 2026.ABSTRACT Rationale Estrogen‐related receptor (ERR) agonists such as the drug candidates SLU‐PP‐332 and SLU‐PP‐915 are currently being investigated as exercise mimetics, given their ability to trigger human physiological processes similar to those initiated by actual physical activity.
Tristan Möller +2 more
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Biomedical Chromatography, Volume 40, Issue 3, March 2026.ABSTRACT Bexicaserin is an investigational molecule that is a highly selective superagonist of the 5‐hydroxytryptamine 2C (5HT2c) serotonin receptor subtype and in Phase 3 clinical studies for the treatment of seizures associated with developmental and epileptic encephalopathies (DEEs).
Raja Reddy Kallem +5 more
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A survey of downstream applications of evolutionary scale modeling protein language models
Quantitative Biology, Volume 14, Issue 1, March 2026.Abstract The evolutionary scale modeling (ESM) series is promising to revolutionize protein science and engineering through large language models (LLMs), providing a robust framework for understanding the relationships among sequences, structures, and functions of proteins.
Qingyu Yang, Jiale Yu, Jie Zheng
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“You Are Safe Now”: Migrant Youth Constructions of Safety and Schooling in the U.S.
Anthropology &Education Quarterly, Volume 57, Issue 1, March 2026.ABSTRACT Drawing on multisited ethnographic research with migrant families from Brazil, El Salvador, Guatemala, and Honduras who were detained, separated, or endured prolonged transit due to US immigration policies, we articulate how ideas of “relational safety” are situated in relationships with people, place, and time. Contrasting abundant literature
Michelle J. Bellino, Gabrielle Oliveira
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NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis
Annals of Clinical and Translational Neurology, Volume 13, Issue 2, Page 270-284, February 2026.ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao +10 more
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Pharmacogenetic Interventions, Orphan Groups, and Distributive Justice: The Role of Cost-Benefit Analysis [PDF]
, 2002 Rai, Arti K.
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CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target
Advanced Science, Volume 13, Issue 8, 9 February 2026.This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang +2 more
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