Results 231 to 240 of about 88,273 (287)

Patents, Innovation and Access to New Pharmaceuticals [PDF]

Henry Grabowski
core  

Loncastuximab Tesirine in a Frail, Heavily Pretreated Patient With Relapsed/Refractory Diffuse Large B‐Cell Lymphoma: A Case Report

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Loncastuximab tesirine may offer a feasible, well‐tolerated option for frail, heavily pretreated patients with relapsed/refractory DLBCL and poor performance status when intensive therapies are unsuitable, achieving durable remission with manageable fluid retention through careful monitoring, spironolactone‐based treatment, and dose ...
Reyad Dada, Refaei Belal Ibrahim
wiley   +1 more source

Targeting Ferroptosis Pathways for Synaptic Protection in Sevoflurane‐Induced Cognitive Impairment: A Nanomedicine Approach

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
Sevoflurane exposure triggers iron‐dependent lipid peroxidation and ferroptosis, leading to synaptic damage and cognitive dysfunction. Targeted nanodelivery systems that cross the blood–brain barrier can precisely modulate ferroptotic pathways, reduce oxidative injury, and rescue synaptic integrity, offering a promising strategy for preventing ...
Bin Zhao, Changming Wang, Mingming Zhang
wiley   +1 more source

A novel MCGDM technique based on correlation coefficients under probabilistic hesitant fuzzy environment and its application in clinical comprehensive evaluation of orphan drugs. [PDF]

PLoS One
Hu Y, Pang Z.
europepmc   +1 more source

Activation of GPR35 in the Anterior Cingulate Cortex Alleviates Neuropathic Pain and Depression‐Related Behavior

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
Sciatic nerve injury led to a significant increase in the expression of GPR35 in the ACC region of mice. This increased interaction with Nr4a1 can activate the PI3K/AKT signaling pathway, thereby reducing neuroinflammation and playing a role in alleviating hyperalgesia and depressive behavior in mice. ACC, anterior cingulate cortex.
Jianling Xu, Jingyong Zhou, Xiaojun Li, Tingting Qu, Changjian Zheng, Qingyu Cheng, Xiuyang Lei, Weidong Yao, Yongquan Chen, Bin Wang   +9 more
wiley   +1 more source

Body Mass Index and Clinical Associations in Australasian Lymphoma Patients: A Lymphoma and Related Diseases Registry Study

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Introduction Overweight and obesity are increasing rapidly in most countries. Underweight body mass index (BMI), though much less common, is also associated with adverse health outcomes. There is poor understanding of the implications of BMI in lymphoma patients.
Serif Sungur, Yao Yao, Cameron Wellard, Eliza Chung, Susan Morgan, Denise Lee, Geoffrey Chong, Chan Y. Cheah, Tasneem Rizvi, Eliza A. Hawkes, Zoe K. McQuilten, Erica M. Wood, Nada Hamad, Tasman Armytage, Anna M. Johnston   +14 more
wiley   +1 more source

Cost of Exempting Sole Orphan Drugs From Medicare Negotiation.

JAMA Intern Med
Vogel M, Zhao O, Feldman WB, Chandra A, Kesselheim AS, Rome BN.   +5 more
europepmc   +1 more source

A Cross‐Sectional Survey of Evidence Needs for Medicinal Products in Europe With a Focus on Real‐World Evidence

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 4, April 2026.
ABSTRACT Purpose To assess views among different stakeholders around evidence needs during assessment of clinical effects across the medicinal product life cycle, with a focus on real‐world evidence (RWE) in regulatory and health technology assessor (HTA)/payer decision‐making.
Maria Melinder, Fabian Windfuhr, Tanja Dahlqvist, Carla Torre, Bruno Sepodes, Peter G. M. Mol, Diogo Almeida, Isabella Ekheden, Nils Feltelius, Kit Roes, Sieta T. de Vries, Björn Wettermark   +11 more
wiley   +1 more source

CRISPR/Cas Genome Editing and Its Applications in Cereal Crop Improvement

Plant-Environment Interactions, Volume 7, Issue 2, April 2026.
ABSTRACT CRISPR/Cas‐based genome editing has emerged as a transformative tool for precise genetic improvement of cereal crops. Recent advances in CRISPR technologies, including Cas9, Cas12, Cas13, base editing, and prime editing, have enabled targeted modification of genes and regulatory elements controlling yield, stress tolerance, and grain ...
Sirisha Kaniganti, Himanshu Saini, A. K. Chaitanya, Niranjan Hegde, Priya Shah, Nakul D. Magar, Ramesh Rijal, Jeevan Jyoti Kaushik, Deepak Nanda, Sharad Sachan, Anand Kumar, Roopali Bhoite, Harsha Rayudu Jamedar   +12 more
wiley   +1 more source

StabLyzeGraph: High‐throughput screening of combinatorial mutations using graph neural networks

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Engineering protein stability is a powerful strategy across biotechnology and medicine, supporting a broad range of applications such as atomic structure determination, discovery of therapeutic molecules, biomanufacturing, diagnostic reagents, industrial biocatalysis, etc.
Muhammad Waqas, Benito Natale, Michele Roggia, Prasenjit Prasad Saha, Mauro Mileni, Sandro Cosconati   +5 more
wiley   +1 more source