Results 231 to 240 of about 88,754 (289)

A novel MCGDM technique based on correlation coefficients under probabilistic hesitant fuzzy environment and its application in clinical comprehensive evaluation of orphan drugs. [PDF]

PLoS One
Hu Y, Pang Z.
europepmc   +1 more source

Patents, Innovation and Access to New Pharmaceuticals [PDF]

Henry Grabowski
core  

Minimal Evidence of Inflammaging in Naturalistic Chimpanzee Populations

American Journal of Biological Anthropology, Volume 189, Issue 2, February 2026.
ABSTRACT Objectives Whereas chronic inflammation is a hallmark of aging in many human populations, inflammaging is reduced in groups characterized by frequent physical activity and diets low in processed foods. Since most biomarkers of inflammation require blood sampling, comparative data from our closest primate relatives have been derived from ...
Megan F. Cole, Melissa Emery Thompson, Nicole Thompson González, Eleanor Paskus, Joshua Rukundo, Rebeca Atencia, Alexandra G. Rosati   +6 more
wiley   +1 more source

The 340B Program: A Federal Program in Desperate Need of Revision After Two-And-A-Half Decades of Uncertainty [PDF]

, 2019
Fisher, Nicholas C.
core   +1 more source

An LC–MS/MS Method for the Quantitation of Metabolites M9, M12, and M20 of Bexicaserin in Human Cerebrospinal Fluid

Biomedical Chromatography, Volume 40, Issue 2, February 2026.
ABSTRACT The investigational molecule bexicaserin is a highly selective 5‐HT2C superagonist currently in Phase 3 clinical studies for the treatment of seizures associated with developmental and epileptic encephalopathies (DEEs). To facilitate its clinical development, a simple LC–MS/MS method was developed and validated for the quantitative estimation ...
Raja Reddy Kallem, Rosa Chan, Maisy Yeager, Katie Neal, Katharine Fletcher, Nuggehally R. Srinivas   +5 more
wiley   +1 more source

Altered Mechanical Properties of Astrocytes Lacking MLC1: Implications for the Leukodystrophy MLC

Glia, Volume 74, Issue 2, February 2026.
Mechanical properties of Mlc1‐null astrocytes are altered. Cytoskeleton‐related pathways are dysregulated in Mlc1‐null astrocytes. Mlc1‐null astrocytes show alterations in focal adhesions, which link the cytoskeleton to the extracellular matrix. ABSTRACT Loss of function of the astrocyte protein MLC1 causes Megalencephalic Leukoencephalopathy with ...
Quinty Bisseling, Emma M. J. Passchier, Freya M. Kirwan, Nelda Antonovaite, Serena Camerini, Maria S. Brignone, Amélie Freal, Huibert D. Mansvelder, Elena Ambrosini, Marjo S. van der Knaap, Rogier Min   +10 more
wiley   +1 more source

Cost of Exempting Sole Orphan Drugs From Medicare Negotiation.

JAMA Intern Med
Vogel M, Zhao O, Feldman WB, Chandra A, Kesselheim AS, Rome BN.   +5 more
europepmc   +1 more source

Transferability of Real World Evidence to Support HTA Recommendations in Lower Income European Countries

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Lower income European countries (LIECs) have more limited financial resources to cover high‐cost technologies in rare diseases than higher income European countries (HIECs). Our study explores how treatment recommendations in myelodysplastic syndrome (MDS) can be supported in LIECS by transferring real‐world evidence (RWE ...
Zoltán Kaló, Guenka Petrova, Bertalan Németh, Petra Došenović Bonča, Diana Delnoij, Alastair Bennett, Konstantin Tachkov, Yingying Zhang, Noemi Kreif, Saskia Knies, Iga Lipska, Tomas Tesar, Zornitsa Mitkova, Johan Ponten, Anders Viberg, Marian‐Sorin Paveliu, Oresta Piniazkho, Adina Turcu‐Stiolica, Tomáš Doležal, Michal Staňák, Alima Almadiyeva, Rok Hren, Dinko Vitezić, Zsuzsanna Petykó, Wim Goettsch, Andrea Manca   +25 more
wiley   +1 more source

Arrhythmic expression signatures of circadian clock‐associated transcription factors and chronic circadian disruption contribute to advanced prostate cancer growth

International Journal of Cancer, Volume 158, Issue 3, Page 775-789, 1 February 2026.
What's new? Circadian rhythm disruption potentially fuels prostate cancer progression. The mechanisms and signaling molecules contributing to hormonal tumorigenesis, however, remain largely undefined. In this study, circadian expression patterns of core‐circadian controlled genes (CCCGs) and nuclear receptors (NRs) were investigated in advanced ...
Ria Chopra, Haolong Li, Wenjuan Xie, Daniel Hau Tak Lam, Franky Leung Chan   +4 more
wiley   +1 more source

Calprotectin Is a Circulating Biomarker and Potential Therapeutic Target for Sarcopenia in Chronic Obstructive Pulmonary Disease

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Sarcopenia, an important complication of chronic obstructive pulmonary disease (COPD), is significantly associated with increased mortality. Systemic inflammation is an important trigger of COPD‐related skeletal muscle dysfunction. Calprotectin is a damage‐associated molecular pattern involved in the inflammatory response, but its ...
Liwei Liao, Jiaye Li, Weidong Xu, Yan Yin, Zilin Wang, Chang Li, Yanxia Li, Xiaoming Zhou, Mingming Deng, Gang Hou   +9 more
wiley   +1 more source