Results 231 to 240 of about 63,288 (330)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

eDakterBari: A human-centered solution enabling online medical consultation and information dissemination for resource-constrained communities in Bangladesh. [PDF]

Heliyon
Eliza IJ, Urmi MA, Anan MTT, Munim MTH, Galib FZ, Islam ABMAA.   +5 more
europepmc   +1 more source

The unbearable (financial) burdens of parenting

The British Journal of Sociology, EarlyView.
Alya Guseva
wiley   +1 more source

Modulation of KATP channels by diazoxide preserves mitochondrial function and barrier integrity under staurosporine‐induced epithelial stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Intestinal barrier dysfunction caused by mitochondrial stress, oxidative damage and apoptosis, are hallmarks of dysbiosis‐associated gastrointestinal (GI) disorders. Staurosporine causes downstream features of dysbiosis‐induced epithelial damage.
Fatima Maqoud, Eleonora Malerba, Simona Drago, Antonella Orlando, Domenica Mallardi, Nicoletta De Lucia, Marina Antonacci, Annamaria Di Turi, Domenico Tricarico, Francesco Russo   +9 more
wiley   +1 more source

The impact of early life experiences on inhibitory control and working memory. [PDF]

Front Psychol
Dydenkova E, McGlone F, Mayorova L, Nikolaeva E.   +3 more
europepmc   +1 more source

v. 24, no. 5, November 26, 1963 [PDF]

, 1963

core   +1 more source

Thrombospondin‐4 is upregulated in abdominal aortic aneurysm: A vasoprotective response with potential therapeutic relevance

British Journal of Pharmacology, EarlyView.
TSP4 is upregulated in human and experimental AAA. TSP4 knockdown accelerated AAA formation and exacerbated both vascular inflammation and remodelling, emphasizing that TSP4 upregulation may represent a protective response against AAA. Our findings suggest that preserving TSP4 could be a useful strategy in the clinical management of AAA.
Laia Blanco‐Casoliva, Lidia Puertas‐Umbert, Judith Alonso, Rafael Almendra‐Pegueros, Saray Varona, Mercedes Camacho, Gemma Arderiu, Lluís Asmarats, Marta Alegret, Jose Martinez‐Gonzalez, Cristina Rodriguez   +10 more
wiley   +1 more source

Caries in orphan children: prevalence and determinants-a systematic review and meta-analysis. [PDF]

BMC Oral Health
Gamal-AbdelNaser A, A Elsabour MAA, Khattab NMA.   +2 more
europepmc   +1 more source

Debate: Young people are living in unprecedented times – too much chaos or too little resilience? Protecting young people in perilous times calls for bolstering multisystem resilience as well as mitigating risk

Child and Adolescent Mental Health, EarlyView.
Young people around the world are threatened by increasing chaos and danger from armed conflicts, natural disasters, climate change, forced displacement, disease epidemics, and related adversities. This perilous situation raises a critical question: Are we doing enough to protect and prepare young people to adapt and thrive?
Ann S. Masten
wiley   +1 more source