Results 31 to 40 of about 9,860 (215)
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Male production by workers in the polygynous ant Prolasius advenus [PDF]
, 2013 The ability of workers to produce male individuals is reported here for the first time in a species of the formicine ant genus Prolasius. We show that Prolasius advenus workers possess ovaries and demonstrate that they are able to produce adult males in ...
Avril, A., Grangier, J., Lester, P.J.
core +1 more source
Charles Dickens and Colonial Expansionism ‘Obscured’ in "When We Were Orphans" by Kazuo Ishiguro
Analyses/Rereadings/Theories: A Journal Devoted to Literature, Film and Theatre, 2023 The intertextual associations with Charles Dickens’s novel Great Expectations in When We Were Orphans seem unobvious. In this paper I will show that Dickensian motifs are nonetheless noticeable in Ishiguro’s novel and, relating to Dickens’s fictionalised biography by Peter Ackroyd, some events from his turbulent life can also be recognised. The concept
openaire +1 more source
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Life Beneath Silk Walls: A Review of the Primitively Social Embiidina [PDF]
, 1997 I review and summarize the scattered information on embiids (Order Embiidina), with an emphasis on details of colony structure and maternal care. I summarize experimental and observational field results from a detailed study on parental and communal ...
Edgerly-Rooks, Janice
core +1 more source
Child Labor in the Gold Coast: The Economics of Work, Education, and the Family in Late-Colonial African Childhoods, c. 1940-57 [PDF]
, 2011 Historical knowledge of childhood in the Gold Coast (modern Ghana) is sparse and too often disconnected from a global historiography that has convincingly demonstrated the "child" to be a social construct. In contemporary discourse the "African child" is
Lord, Jack
core +1 more source
, 2020 This dissertation examines the “rescue” missions of indigenous famine orphans by mostly nonstate actors in colonial north and west India from the late nineteenth to the early twentieth century. By the late nineteenth century, indigenous famine orphans, like “native” women, had become a site of social, political, religious, and economic contestation ...
openaire +2 more sources
Advanced Intelligent Discovery, EarlyView.Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova +4 more
wiley +1 more source
RORγt‐APCs: The New Masters of Oral Tolerance
Barrier Immunity, EarlyView.ABSTRACT Oral tolerance is defined by the hypo‐responsiveness of our body to fed antigens, and its failure can lead to immune‐mediated diseases, such as allergy, chronic inflammation and autoimmune diseases. Decades of research have demonstrated that antigen‐presenting cells (APCs) promote oral tolerance by inducing regulatory T cells (Tregs) and/or ...
Thierry Gauthier, WanJun Chen
wiley +1 more source
Sociobiology, 2013 Reproductive systems of termite colonies may involve the number of individuals in the reproductive caste and the copulatory selectivity of reproductive individuals (i.e., polyandry or polygamy), both of which directly impact the fertility and genetic ...
Jia Wu +4 more
doaj