Results 111 to 120 of about 29,818 (295)

A Phase I study of the pharmacokinetics (PK), bioavailability, dose proportionality, safety, and tolerability of topiramate injection compared to Oral topiramate in healthy adult participants

open access: yesEpilepsia, EarlyView.
Abstract This Phase I study evaluated the safety, tolerability, and pharmacokinetics of a 30‐min topiramate injection (intravenous [IV] TPM) infusion compared with oral topiramate (oral TPM) in healthy adult participants. In this randomized, open‐label, dose escalation, crossover study with 37 healthy participants received single doses of 50, 100, or ...
Adeboye O. Bamgboye   +3 more
wiley   +1 more source

The Socioeconomic Impact of HIV/AIDS on Education Outcomes in Uganda: School Enrolment and the Schooling Gap in 2002/03 [PDF]

open access: yes
Due to high prime-age mortality in Uganda, a result of the HIV/AIDS scourge, the number of children who have lost at least one parent continues to rise in the country.
Hisali, Eria, Kasirye, Ibrahim
core  

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

open access: yesEpilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang   +3 more
wiley   +1 more source

Phenotype‐guided etiologic workup in a prospective cohort of 144 adults with developmental and epileptic encephalopathy

open access: yesEpilepsia Open, EarlyView.
Abstract Objectives Adults with developmental and epileptic encephalopathies (DEEs) often enter adult neurology care without etiologic clarification because of incomplete transition from pediatric services, outdated investigations, and attenuation of childhood electro‐clinical features over time.
Giuseppe d’Orsi   +10 more
wiley   +1 more source

Nigeria research situation analysis on orphans and other vulnerable children [PDF]

open access: yes, 2009
This item is archived in the repository for materials published for the USAID supported Orphans and Vulnerable Children Comprehensive Action Research Project (OVC-CARE) at the Boston University Center for Global Health and Development.Addressing the ...
Brooks, Bram   +5 more
core   +1 more source

From first seizure to specific antiseizure medication in Dravet syndrome: Quantifying delays in the DS'coverED study

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Dravet syndrome (DS) is a rare early‐onset developmental and epileptic encephalopathy with persistent delays between seizure onset and diagnosis. The DS'coverED study aimed to characterize current diagnostic timelines by examining each step and its duration, identifying residual barriers, and actionable solutions to optimize the ...
Loucas Christodoulou   +9 more
wiley   +1 more source

Essex Orphans Court with Julia Ursin Niemcewicz Kean, June 7, 1834 [PDF]

open access: yes
Indenture from Essex Orphans Court with Julia Ursin Niemcewicz Kean giving Sarah Sabina Baker, her mother and guardian control of her accounts.https://digitalcommons.kean.edu/lhc_1830s/1086/thumbnail ...
Essex Orphans Court
core  

Effectiveness and safety of cannabidiol in adult patients with epilepsy: A multicenter, retrospective study

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Cannabidiol (CBD) has demonstrated promising effectiveness and tolerability as adjunctive treatment in patients with severe childhood epilepsies. This study investigated the effectiveness and tolerability of CBD in adults with a history of Dravet syndrome (DS), Lennox–Gastaut syndrome (LGS), or tuberous sclerosis complex (TSC ...
Sara Sánchez‐Gamino   +7 more
wiley   +1 more source

DIAGNOSTIC ORPHANS [PDF]

open access: yesAddiction, 2011
Rajat, Ray, Anju, Dhawan
openaire   +2 more sources

Bioavailability through lactic fermentation in millet for combating hidden hunger

open access: yesFood Biomacromolecules, EarlyView.
Millets are nutrient‐rich grains with considerable potential to combat hidden hunger, but the presence of anti‐nutritional factors, can restrict mineral bioavailability. Processing strategies including soaking, germination, cooking, and lactic acid fermentation can reduce the anti‐nutritional factors.
Ajina Anila Sugathan   +3 more
wiley   +1 more source

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