Results 151 to 160 of about 12,462 (264)

MicroRNAs as potential architects of immune dysregulation and megakaryocytic failure in immune thrombocytopenia

British Journal of Haematology, EarlyView.
Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu, Johan Rebetz, Lamya Garabet, Waleed Ghanima, Peipei Xu, Hans Wadenvik, Drew Provan, Rick Kapur, John W. Semple   +8 more
wiley   +1 more source

Outcome of treatment with trametinib in adults with histiocytic neoplasms in the United Kingdom

British Journal of Haematology, EarlyView.
Trametinib (MEK inhibitor) shows efficacy in refractory and high‐risk adult histiocytic neoplasms. At a median follow‐up of 21.4 months, the clinical response rate was 81% (30/37) and the radiological response was 68% (25/37) (n = 37).
Rodothea Amerikanou, Talha Munir, Kristian Bowles, Christopher McNamara, Nikesh Chavda, Elizabeth Price, Jagdish Adiyodi, Alasdair Coles, Philippa Kelsey, Jeffery Smith, Richard Adams, Hayder Hussein, Rui Zhao, Trung Nguyen, Matthew Collin, Satyen Gohil   +15 more
wiley   +1 more source

Fecal glucocorticoid metabolite and T3 profiles of orphaned elephants differ from non-orphaned elephants in Zambia. [PDF]

PeerJ
Chusyd DE, Brown JL, Paris S, Boisseau N, Mwaanga W, Kasongo M, Olivier L, Dickinson SL, Ortyl B, Steiniche T, Austad SN, Allison DB, Wasserman MD.   +12 more
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Suicidal Ideation and Resilience Among Orphan and Non-orphan Adolescents in the Indian City of Pune. [PDF]

Ann Neurosci
Basu T, Dangwal P, Deokar M.
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Under the radar: a longitudinal exploration of mental health among children and adolescents experiencing parental and caregiver death during the COVID‐19 pandemic in South Africa

Child and Adolescent Mental Health, EarlyView.
Background Death of a caregiver during childhood can have profound influences on child wellbeing and later trajectories. Globally, child and adolescent mental health is an increasing area of concern with widespread negative implications. These data provide the first comprehensive exploration of the mental health of children experiencing COVID‐19 ...
Kathryn Steventon Roberts, Christina A. Laurenzi, Tatenda Mawoyo, Stefani Du Toit, Mark Tomlinson, Lucie Cluver, Lorraine Sherr   +6 more
wiley   +1 more source

Prevalence and risk factors of scabies among orphans: A cross-sectional study in Bangladesh. [PDF]

PLoS Negl Trop Dis
Rafi MA, Hossain MG, Hasan MR, Hasan MJ.
europepmc   +1 more source

Intestinal STING‐(Over)activation—A Contributing Factor to Food Allergies?

Allergy, EarlyView.
Sophie Goebel, Hannah Ruth Schiller
wiley   +1 more source

Expectations and Concerns of Adoptive Families of Children With Fetal Alcohol Spectrum Disorder

Child &Family Social Work, EarlyView.
ABSTRACT Fetal alcohol spectrum disorder (FASD) is considered a condition that persists throughout life in people who have been exposed to alcohol during the gestation period. During the different stages of their lives, individuals with FASD face different challenges and adversities that—without the right resources and strategies—can contribute to ...
Dídac Gómez‐Santabrígida, Carme Montserrat, Marta Garcia‐Molsosa, Gala Lima‐López   +3 more
wiley   +1 more source