Results 61 to 70 of about 96,771 (257)

Use of bacterial whole-genome sequencing to investigate local persistence and spread in bovine tuberculosis

Epidemics, 2016
Mycobacterium bovis is the causal agent of bovine tuberculosis, one of the most important diseases currently facing the UK cattle industry. Here, we use high-density whole genome sequencing (WGS) in a defined sub-population of M.
Hannah Trewby, David Wright, Eleanor L. Breadon, Samantha J. Lycett, Tom R. Mallon, Carl McCormick, Paul Johnson, Richard J. Orton, Adrian R. Allen, Julie Galbraith, Pawel Herzyk, Robin A. Skuce, Roman Biek, Rowland R. Kao   +13 more
doaj   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Unprecedented Association: Bilateral UPJ obstruction with grade 3 hydronephrosis caused by Type 2 circumcaval right ureter and left lower pole crossing vessels

Urology Case Reports
Bilateral ureteropelvic junction obstruction resulting from distinct vascular anomalies on each side, with a pre-ureteric vena cava on the right and crossing vessels on the left, has not been previously documented in the literature.
Mohammed Salah E. Khalifa Salem, Abdul Alherek, Daniel DaSilva, Jacob Varghese, Alain Mwamba Mukendi   +4 more
doaj   +1 more source

Advances and Perspectives in Graphene‐Based Quantum Dots Enabled Neuromorphic Devices

Advanced Science, EarlyView.
Graphene‐based QDs are zero‐dimensional carbon nanomaterials with pronounced quantum confinement and tunable electronic structures. Herein, we summarize their synthesis strategies and functionalization methods, and highlight their functional roles and operating mechanisms in devices, as well as recent advances in neuromorphic electronics. We anticipate
Yulin Zhen, Wei Zeng, Zherui Zhao, JiYu Zhao, Ziyan Huang, Zhuo Chen, Kui Zhou, Guanglong Ding, Su‐Ting Han, Ye Zhou   +9 more
wiley   +1 more source

Noninvasive Characterization of Tumor Heterogeneity in HNSCC: From Clinical Utility to Biological Correlates

Advanced Science, EarlyView.
This study establishes a CT‐based radiomics framework to quantify intratumoral heterogeneity (ITH) in HNSCC. Using unsupervised clustering, tumor ROIs and VOIs are analyzed to calculate 2D/3D ITH scores. The score shows strong predictive value for prognosis and immunotherapy response, and is associated with tumor metabolism and immune microenvironment,
Xinwei Chen, Rui Liu, Yuan Zhou, Yin Xiao, Chengmin Feng, Lin Chen, Yanshi Li, Mengna Wang, Zhaobo Cheng, Yuxi Luo, Long Liu, Lijing Niu, Yue Xiang, Juan Peng, Guohua Hu, Min Pan   +15 more
wiley   +1 more source

Combining genomics and epidemiology to investigate a zoonotic outbreak of rabies in Romblon Province, Philippines

Nature Communications
Rabies is a viral zoonosis that kills thousands of people annually in low- and middle-income countries across Africa and Asia where domestic dogs are the reservoir. ‘Zero by 30’, the global strategy to end dog-mediated human rabies, promotes a One Health
Mirava Yuson, Criselda T. Bautista, Eleanor M. Rees, Carlijn Bogaardt, Van Denn D. Cruz, Rowan Durrant, Anna Formstone, Daria L. Manalo, Duane R. Manzanilla, Mikolaj Kundergorski, Leilanie Nacion, Hannaniah Aloyon, Jude Karlo Bolivar, Jeromir Bondoc, Christina Cobbold, Efraim Panganiban, Shynie Vee. M. Telmo, Jobin Maestro, Mary Elizabeth G. Miranda, Nai Rui Chng, Kirstyn Brunker, Katie Hampson   +21 more
doaj   +1 more source

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

John Boyd Orr, Baron Boyd Orr of Brechin Mearns, 1880-1971 [PDF]

Biographical Memoirs of Fellows of the Royal Society, 1972
Abstract John Boyd Orr was born on 23 September 1880 at Kilmaurs, Ayrshire. His father, Robert Clark Orr, was a quarry owner in a small way of business whose interests ranged widely. ‘A remarkable man of great ability’, he had not only deep religious convictions as an earnest, practising member of a sect of the Free Church of Scotland
openaire   +2 more sources

High Free‐Volume Imidazole‐Based Ionomers for High‐Temperature Proton Exchange Membrane Fuel Cells

Advanced Science, EarlyView.
High free‐volume imidazole‐based ionomers (PF4IM‐72) enable enhanced phosphoric acid uptake and efficient proton transport, delivering peak power densities of 0.645 W cm−2 at 160 °C and 0.838 W cm−2 at 200 °C in HT‐PEMFCs. This work highlights a promising platform for next‐generation ionomers with improved high‐temperature performance and stability ...
Ge Chao, Hyeon Keun Cho, Chang Yeon Hyun, Shirong Li, Jong Geun Seong, So Young Lee, Nanwen Li, Young Moo Lee   +7 more
wiley   +1 more source

The benefits of artificial intelligence for nursing operational managers in South African public hospitals

International Journal of Africa Nursing Sciences
Background: Artificial intelligence is the greatest technological revolution of the 21st century with enormous benefits. Nursing operational managers of South African public hospitals are expected to implement artificial intelligence in their nursing ...
Sanele E. Nene
doaj   +1 more source