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Orthobiologic Use in Sports Injuries
Clinics in Podiatric Medicine and Surgery, 2023Orthobiologics have gained much popularity in recent years but there has not been a large amount of clinical evidence to support their use. In the limited research that has been published, they have been shown to be effective and safe. They can assist in earlier return to activity with the avoidance of surgery.
Lawrence M, Oloff +2 more
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Regional Anesthesia for Orthobiologic Procedures
Physical Medicine and Rehabilitation Clinics of North America, 2023Peripheral nerve blocks (PNB) can lessen procedural pain and eliminate the known detrimental effects of our local anesthetics on our orthobiologic target tissues. Local nerve damage and local anesthetic systemic toxicity are risks of PNBs that can be minimized with meticulous injection technique and an understanding of why these complications can occur.
Michael, Khadavi +4 more
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Orthobiologic Treatment of Ligament Injuries
Physical Medicine and Rehabilitation Clinics of North America, 2023Ligament injuries are common causes of joint pain, dysfunction, and disability resulting in disruption of joint homeostasis. Ligament injuries have historically been treated surgically. The autologous orthobiologic preparation used for treatment can influence the varying results reported.
Luga, Podesta +3 more
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Basic Science of Allograft Orthobiologics
Physical Medicine and Rehabilitation Clinics of North America, 2023Orthobiologic procedures are based on altering the microenvironment of musculoskeletal tissues to induce an anti-inflammatory effect and reduce pain, promote healing of these tissues, or provide mechanical support. Allograft tissues have these inherent qualities and can be used as such.
Alberto J, Panero +4 more
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Orthobiologic Techniques for Surgical Augmentation
Physical Medicine and Rehabilitation Clinics of North America, 2023General awareness and clinical utilization of orthobiologic therapy has increased sharply in the recent years. Orthobiologics can be defined as "biological materials and substrates that promote bone, ligament, muscle, and tendon healing." There are 3 major strategies by which orthobiologics are thought to augment tissue repair or native biologic ...
Kenneth M. Lin +5 more
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Orthobiologics and platelet rich plasma
Orthobiologics have evolved to the extent that they significantly influence modern orthopedic surgical practice. A better understanding of the role of various growth factors and cells in the process of tendon healing, ligament repair, cartilage regeneration and bone formation has stimulated focused research in many chronic musculoskeletal ailments ...
Prateek Behera +2 more
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Orthobiologics for Cartilage Repair
Clinics in Sports MedicineOrthobiologics are substances derived from biological sources and are increasingly used in cartilage repair. Mesenchymal signaling cells (MSCs) play a crucial role in cartilage regeneration, but face challenges in clinical application. Platelet-rich plasma, concentrated bone marrow aspirate, adipose tissue, and human umbilical cord blood have all ...
Yusuf N, Mufti +5 more
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Orthobiologics in Muscle Injury
Clinics in Sports MedicineMuscle injuries are a frequent concern in competitive athletes and military personnel, often hindering their ability to continue in their sport or service. Due to the significant impact of these injuries and the urgency of returning to activity, orthobiologics such as prolotherapy, platelet-rich plasma, and mesenchymal stem cells have been explored as ...
Lindsey G, Droz +2 more
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Protocols and Techniques for Orthobiologic Procedures
Physical Medicine and Rehabilitation Clinics of North America, 2023Many procedural techniques have been described and used for orthobiologics procedures with little research on the ideal technique. This section outlines the commonly used materials and techniques from start to finish for these procedures. Post-procedure pain is common during and after many of these injections, and local and regional anesthesia during ...
Michael, Khadavi +2 more
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Economic Realities of Orthobiologics
Clinics in Sports MedicineThe economic dynamics of orthobiologics are complex and influenced by insurance coverage, regulatory pathways, marketing practices, health care settings, and geographic location. Limited insurance coverage and ambiguous guidelines may lead to significant out-of-pocket expenses to patients and variable costs for the health care system.
Jared P, Sachs +4 more
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