Results 241 to 250 of about 996,469 (291)

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

Advanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim, Minju Lee, Yiming Wang, Eunjin Choi, Ji Sun Park, Kyungmin Park, Hayoung Jeon, Donghyun Kim, Donghyun Lee, Yeeun Lee, Kee‐Pyo Kim, Eunha Kim, Heebeom Koo   +12 more
wiley   +1 more source

Fabrication and optimization of camptothecin loaded Eudragit S 100 nanoparticles by Taguchi L4 orthogonal array design.

Int J Pharm Investig, 2015
Mahalingam M, Krishnamoorthy K.
europepmc   +1 more source

A Denoising Preprocessing Framework via Orthogonal Multi-Tap Null-Steering Beamformer Bank: Facilitating Target Signal Preservation Under Low SINR Conditions and Complex Soundscapes. [PDF]

Sensors (Basel)
Chen L, Xu Z, Su P, Zhao Z.
europepmc   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Acoustic Tweezers-Assisted Biomaterial Molding in Petri Dishes (TAMP) for Engineering Glioma Tissues With Controlled Cellular and Extracellular Matrix Architectures. [PDF]

Small
Du Y, Li J, Liu H, Arroyo JP, Bo L, Cai B, Li T, Wang Z, Qiu C, Davalos R, Rich J, Tian Z.   +11 more
europepmc   +1 more source

Joint Estimation of Coherent Signal DOA and Polarization Parameters Based on Improved BSBL. [PDF]

Sensors (Basel)
Du Y, Peng J, Hu D, Wang J, Zeng H.
europepmc   +1 more source

Extracellular Vesicle Surface Protein Profiling in Metabolic Dysfunction-associated Steatotic Liver Disease in Obesity. [PDF]

J Extracell Biol
Garcia NA, Kløve-Mogensen K, Cliff KL, Bæk R, Ulanowska M, Quezada JAD, Jørgensen MM, Handberg A, Mellergaard M.   +8 more
europepmc   +1 more source

Real-Time Biplane Versus Single-Plane US-guided Hip Joint Injection: A Single-Center Prospective Study. [PDF]

Orthop J Sports Med
Zhao G, Li C, Sun H, An P, Wang Y, Zhang M.   +5 more
europepmc   +1 more source

Electro-optic modulation of coherent and incoherent mid-IR radiation in two-dimensional arrays. [PDF]

Sci Adv
Sisler J, Pearson P, Kelzenberg M, Faraon A, Atwater HA.   +4 more
europepmc   +1 more source