Results 201 to 210 of about 118,006 (248)

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Chip-integrated polarization multiplexed metasurface for simultaneous generation of versatile terahertz vortices. [PDF]

Nanophotonics
Zhang Q, Li G, Wu L, Yang F, Yue Z, Zheng C, Zhang Y, Li L, Yao J.   +8 more
europepmc   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Differential Reflecting Frequency Modulation with QAM for RIS-Based Communications. [PDF]

Sensors (Basel)
Fan Y, Zhao L, Yan W, Ma H.
europepmc   +1 more source

Atomic Defects in Layered Transition Metal Dichalcogenides for Sustainable Energy Storage and the Intelligent Trends in Data Analytics

Advanced Science, EarlyView.
This review comprehensively summarizes the atomic defects in TMDs for their applications in sustainable energy storage devices, along with the latest progress in ML methodologies for high‐throughput TEM data analysis, offering insights on how ML‐empowered microscopy facilitates bridging structure–property correlation and inspires knowledge for precise ...
Zheng Luo, Ying Yang, Zizhen Fu, Fengqi Liu, Susu Fang, Kele Xu, Shanshan Wang   +6 more
wiley   +1 more source

Robust and efficient image transmission in power-constrained underwater visible light communication systems using neural architecture search. [PDF]

Sci Rep
Jin Q, Deng B, Fu HY, Khan FN.
europepmc   +1 more source

Kinesin‐Induced Buckling Reveals the Limits of Microtubule Self‐Repair

Advanced Science, EarlyView.
This study shows that kinesin‐driven buckling induces extensive microtubule lattice damage that often exceeds intrinsic self‐repair and leads to filament failure. While curvature, motor motility, and force individually cause limited damage, their combination overwhelms repair.
Shweta Nandakumar, Jonas Bosche, Mirko Wieczorek, Constantin Matteo Albrecht, Belinda König, Mona Grünewald, Ludger Santen, Stefan Diez, Reza Shaebani, Laura Schaedel   +9 more
wiley   +1 more source

Nonreciprocal transmission based on quasi-bound states in the continuum via scaled lattice constants. [PDF]

Nanophotonics
Li R, Sun J.
europepmc   +1 more source

Nonrelativistic Spin Current Generated Unconventional Spin Hall Magnetoresistance in Altermagnetic RuO2

Advanced Science, EarlyView.
It is reported that the unconventional spin Hall magnetoresistance generated from nonrelativistic spin currents in RuO2 is capable of accurately detecting spin current polarization and disentangling the T̂$\hat{T}$‐odd and T̂$\hat{T}$‐even components of a spin current.
Chang Pan, Shuai Hu, Fanli Yang, Dongchao Yang, Wei Zhu, Jianwei Zhang, Weijia Fan, Zhong Shi, Liqing Pan, Shiming Zhou, Xuepeng Qiu   +10 more
wiley   +1 more source

Cascaded metasurface for polarization-dependent varifocal vortex beam manipulation. [PDF]

Nanophotonics
Xu W, Zhao C, Li H, Li J, Tan Q, Liu Y, Xu H, Shen Y, Yao J.   +8 more
europepmc   +1 more source