Results 141 to 150 of about 66,312 (263)

Active site diversification of a non‐canonical amino acid decarboxylase by merging substrate multiplexed screening with computationally guided recombination

open access: yesProtein Science, Volume 34, Issue 11, November 2025.
Abstract Recombination of active site mutations is a powerful strategy to alter enzyme activity. The vastness of sequence space, however, often limits screening‐based engineering to single and double site libraries. Here, we explore focused recombination across five positions that enclose the active site of a tryptophan (Trp) decarboxylase.
Allwin D. McDonald   +4 more
wiley   +1 more source

Implementasi dan Evaluasi Kinerja Orthogonal Frequency Division Multiplexing (OFDM) Menggunakan WARP

open access: yesJurnal Teknik ITS, 2015
Salah satu permasalahan dalam perkembangan teknologi telekomunikasi yaitu bagaimana mencapai data rate yang besar namun dengan bandwidth yang tidak lebih besar dari bandwidth koheren kanal untuk menghindari terjadinya Inter-Symbol Interference (ISI ...
Hasan Hasan   +2 more
doaj  

“Lock and Key”: Binding Behavior of Malachite Green and Functional Nucleic Acids and Their Multidimensional Applications

open access: yesSmall Structures, Volume 6, Issue 11, November 2025.
The review comprehensively summarizes the binding behaviors and multidimensional applications of malachite green with diverse functional nucleic acids. By integrating structural mechanisms, comparative analysis, and application strategies across eight domains, it provides theoretical guidance and future perspectives for developing intelligent nucleic ...
Keren Chen   +4 more
wiley   +1 more source

The Serum Lipid Profile of Relapsing Multiple Sclerosis Differs Reproducibly From Healthy Controls

open access: yesJournal of Neurochemistry, Volume 169, Issue 11, November 2025.
Blood biomarkers that correlate with inflammatory demyelination or neurodegeneration are needed for early diagnosis and disease monitoring in multiple sclerosis. This study employed lipidomic analysis to identify serum lipids that are reproducibly altered in relapsing–remitting multiple sclerosis (RRMS) across two independent sample cohorts, finding ...
Lisa Shi   +16 more
wiley   +1 more source

Synaptic and Non‐Synaptic Functions of PTPRD: A Receptor Tyrosine Phosphatase at the Crossroads of Neural Circuitry and Metabolism

open access: yesJournal of Neurochemistry, Volume 169, Issue 11, November 2025.
PTPRD (receptor‐type protein tyrosine phosphatase delta) translates extracellular adhesion “codes” into intracellular phosphotyrosine signaling that shapes brain circuits. Alternative inclusion of micro‐exons meA and meB sculpts PTPRD's Ig domain, dictating trans‐synaptic binding to partners such as IL1RAPL1 or IL1RAP and thereby tuning synapse ...
Seoyeong Kim   +4 more
wiley   +1 more source

Contactless Detection of Abnormal Breathing Using Orthogonal Frequency Division Multiplexing Signals and Deep Learning in Multi-Person Scenarios. [PDF]

open access: yesIEEE Open J Eng Med Biol
Ullah M   +9 more
europepmc   +1 more source

Unlocking grass leaf development: foundations for tunable cereal design

open access: yesNew Phytologist, Volume 248, Issue 4, Page 1655-1676, November 2025.
Summary The grass leaf plays a critical role in global food security, generating the carbon stores in cereal grains, which provide > 50% of global calories. As the global population grows, there is an urgent need to increase food production using fewer resources and to develop more resilient agricultural systems to withstand variable climate conditions
Trisha McAllister   +3 more
wiley   +1 more source

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