Results 81 to 90 of about 190,075 (318)

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

The use of newly isolated fungal cultures for the selective delignification of bamboo culms

Frontiers in Bioengineering and Biotechnology, 2023
The screening of ligninolytic enzyme-producing fungal species in samples led to the identification of Paracremonium sp. LCB1, Clonostachys compactiuscula LCD1 and C. compactiuscula LCN1.
Bo Zhao, Rui Liu, Qi Guo, Gang Xu, Li Zhang, Peng Sun, Ying Cao, Shanglian Hu   +7 more
doaj   +1 more source

Grey-box radial basis function modelling [PDF]

, 2011
A fundamental principle in data modelling is to incorporate available a priori information regarding the underlying data generating mechanism into the modelling process.
Xia Hong, Hong, Xia, Sheng Chen, Chris J. Harris, Chen, Sheng, Harris, Chris J., Harris, Chris   +6 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Multi-objective optimization of laser cladding parameters for 42CrMo surface based on GA-BP and NSGA-II algorithms

Hanjie xuebao
In order to solve the defects such as pits and microcracks on the surface of 42CrMo bearings, the repair process parameters matched by the high-strength steel of the main bearing were obtained.
Shun JIANG, Haiming ZHAO, Xianqiong ZHAO, Dongsheng LI, Lunlei YANG   +4 more
doaj   +1 more source

MECHANICAL RESEARCH AND OPTIMIZATION OF BANANA STALK FIBER EXTRACTION [PDF]

Engenharia Agrícola
Banana stalk production for fiber is an important crop activity in southern China. The fiber extraction technology used has a great impact on the effectiveness and quality of the fiber from banana stalks.
Li Yue, Gao Yang, Huang Chun, Wei Shiquan, Li Yuan, Liang Dong   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Variables and levels for orthogonal test. [PDF]

, 2013
Variables and levels for orthogonal test.
Chunxiang Qian (289582), Yidong Xu (289581)   +1 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source