Results 131 to 140 of about 71,899 (262)

Astrocytic Ketogenesis Protects Central Nervous System Injury via CPT1A Stabilization and Epigenetic Regulation

open access: yesAdvanced Science, EarlyView.
A distinct astrocyte subpopulation, enriched at the lesion border, drives CNS repair through enhanced ketone body metabolism. This process promotes neuronal survival and axonal sparing via CPT1A stabilization and H3K9bhb‐dependent epigenetic reprogramming, positioning astrocytic ketogenesis as a promising therapeutic target for tissue regeneration ...
Dishui Pan   +14 more
wiley   +1 more source

Femoral bone remodelling following cemented hip arthroplasty in a sheep model / Allan W. Wang. [PDF]

open access: yes, 1998
Bibliography: leaves 198-219.xii, 219 leaves : ill. (chiefly col.) ; 30 cm.Examines the effect of implant design on the femoral bone remodelling response in a sheep cemented hip arthroplasty model.
Wang, Allan W. (Allan Wen Li)
core  

Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming

open access: yesAdvanced Science, EarlyView.
Large oncosomes systemically reprogram bone marrow mesenchymal stem cells through innate nucleic acid sensing, driving inflammatory and immunosuppressive remodeling that supports a metastasis‐permissive bone marrow environment, revealing a novel tumor‐host communication axis in cancer. ABSTRACT Bone metastasis can be facilitated by systemic remodeling,
Taylon Felipe Silva   +18 more
wiley   +1 more source

Orthopaedics' megalomania - myth or mobbing?

open access: yes, 2016
INTRODUCTION: It is a general impression in the world of medicine that orthopaedic surgeons differ from doctors of other specialities in terms of intellect and self-confidence. The purpose of this study was to evaluate the self-confidence of orthopaedics.
Brand, Eske   +3 more
core  

The Contributions of Kenelm Hutchinson Digby to Orthopaedics in Hong Kong Part 1

open access: yes, 2015
Professor Kenelm Hutchinson Digby (1884–1954) was the first Professor of Surgery at the University of Hong Kong. He contributed extensively to the understanding of many aspects of orthopaedics and should be regarded as the originator of orthopaedics in ...
Louis Fu
core   +1 more source

A Programmable Braided Silk‐Glass Fiber Ligament Promoting Rapid Motoric Recovery

open access: yesAdvanced Science, EarlyView.
A scalable three‐dimensional braiding strategy integrates silk and glass fibers into customizable artificial ligaments with programmable “J‐shaped” nonlinear mechanics. The silk‐rich architecture supports osseoligamentous integration, while glass fibers provide mechanical reinforcement and biomimetic mineralization cues, enabling strain‐adaptive load ...
Changbo Lu   +16 more
wiley   +1 more source

A Multi‐Structural Radiomic Digital Phenotyping Framework for Deciphering Preclinical Evolution of Degenerative Meniscal Tears

open access: yesAdvanced Science, EarlyView.
Subclinical matrix disruption precedes degenerative meniscal tears across the knee joint. A spatial compartmental radiomics model utilizing 3D‐DESS MRI captures early osteochondral destabilization, accurately predicting incident tears up to four years pre‐collapse. Feature attributions uncover coordinated chondral and osseous alterations, advancing non‐
Shengfa Li   +13 more
wiley   +1 more source

A finite element simulator for spine orthopaedics with haptic interface

open access: yes, 2008
A finite element simulator for spine orthopaedics with haptic ...
Ian Gibson (13074186), G Zhan (13640128)
core  

Rational Surface Engineering Reduces Advanced Glycation End‐Product Adsorption and Improves Implant Integration

open access: yesAdvanced Science, EarlyView.
Targeted surface chemical modification prevents the accumulation of advanced glycation end products (AGEs) on implant surfaces, attenuates inflammation and fibrosis, effectively restores angiogenic activity, and improves osseointegration under diabetic conditions.
Thien Ngoc Le   +13 more
wiley   +1 more source

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