Results 121 to 130 of about 525,147 (293)

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

open access: yesAdvanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li   +12 more
wiley   +1 more source

Deep Learning-Based Workflow for Bone Segmentation and 3D Modeling in Cone-Beam CT Orthopedic Imaging

open access: yesApplied Sciences
In this study, a deep learning-based workflow designed for the segmentation and 3D modeling of bones in cone beam computed tomography (CBCT) orthopedic imaging is presented.
Eleonora Tiribilli, Leonardo Bocchi
doaj   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

open access: yesAdvanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong   +6 more
wiley   +1 more source

"REMEMBER THERE ARE HIDDEN FLAMES IN SURGICAL PRACTICE" [PDF]

open access: yesBasrah Journal of Surgery, 2011
Thamer A Hamdan
doaj   +1 more source

Conformable Microelectrode Arrays Integrated with a Scoop‐Shaped Slide‐Well for Dynamic Electrophysiological Profiling of Patient‐Derived Cardiac Organoids

open access: yesAdvanced Science, EarlyView.
A flexible, ultrathin multi‐channel microelectrode array (MEA) conformally integrated onto a curved slide‐well enables stable electrical interfacing with 3D cardiac organoids. The geometry‐guided self‐alignment allows simultaneous recording of extracellular field potentials and contractile motion from irregular, beating tissues.
Ye Seul Kim   +12 more
wiley   +1 more source

Barnes Hospital Record [PDF]

open access: yes, 1956
https://digitalcommons.wustl.edu/bjc_barnes_record/1108/thumbnail ...

core   +1 more source

Orthopedic Dermatopathies: Skin Manifestations in Orthopedic Conditions

open access: yesJournal of Orthopaedics and Sports Medicine
Orthopedic diseases often present with dermatological symptoms that require prompt identification for appropriate treatment. Understanding these dermatologic presentations is crucial for accurate diagnosis and effective management. This article critically reviewed the dermatological manifestations observed in general and regional pathologies, followed ...
Eskandar, Tony   +2 more
openaire   +2 more sources

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

open access: yesAdvanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li   +16 more
wiley   +1 more source

Introducing a new technique for limb prepping in orthopedic surgeries: Designing, construction, and evaluation of limb-lifting assistive device [PDF]

open access: yes, 2015
Lifting and holding patients' limbs while preparing the skin for orthopedic surgeries may be a lengthy process causing work-related musculoskeletal disorders (MSDs) for preoperative team members.
Mojeni, M.T., Najafi, S.A., Nomali, M.
core  

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