Results 211 to 220 of about 548,360 (345)

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

Advanced Science, EarlyView.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao, Ruohui Han, Hui Xiong, Qian Li, Shaofei Tao, Xudong Wu, Dayong Liu   +6 more
wiley   +1 more source

Evaluating ChatGPT's Ability to Answer Common Parent Questions on Avascular Necrosis in Children. [PDF]

HSS J
Smith GB, Hofmann GH, Gussner AV, Duru NO, Laureano TA, Meadows MC, Chan C, Shea KG.   +7 more
europepmc   +1 more source

Processing and Characterization of 3D Dense Chitosan Pieces, for Orthopedic Applications, by Adding Plasticizers

, 2015
Lígia Figueiredo, Carla Moura, Luís F.V. Pinto, Frederico Castelo Ferreira, Alexandra Rodrigues   +4 more
openalex   +1 more source

Advancing the Tendinopathy Triad: Comment on “Tendinopathy: The Interplay Between Mechanical Stress, Inflammation, and Vascularity”

Advanced Science, EarlyView.
Abstract Building upon the integrative framework of tendinopathy proposed by Gehwolf et al.—which elegantly connects mechanical stress, inflammation, and vascularity—this commentary extends the discussion by introducing novel mechanistic insights and future research directions that move beyond the established triad. A paradigm shift is proposed ...
DuJiang Yang, Jiexiang Yang, Shuang Wang, GuoYou Wang   +3 more
wiley   +1 more source

Nutritional screening tools as predictors of surgical outcomes in geriatric orthopedic patients: a meta-analysis. [PDF]

Aging Clin Exp Res
Li D, Shi J, Zheng J, Hu Y.
europepmc   +1 more source

Risk factors associated with distal humeral fractures: A radiological study of Nigerians admitted at National Orthopedic Hospital, Igbobi, Lagos State, Nigeria

, 2014
V. C. Ezeuko, Agbonluai Richard Ehimigbai, EL Esechie   +2 more
openalex   +1 more source

1998 Survey of Rhode Island Law: Legislation: Evidence: Evidence of Charges for Medical and Hospital Services for Prescriptions and Orthopedic Appliances - Evidence Required from Hospital Medical Records [PDF]

, 1999
Fazendeiro, Rory Zack
core   +1 more source

Immunoaffinity‐Mimetic Assembly of Peptide‐Aptamer Conjugates and Stem Cell‐Derived Exosomes into Hierarchical Microgels for Spinal Cord Injury Repair

Advanced Science, EarlyView.
Inspired by antibody‐antigen binding, this study develops an unprecedented immunoaffinity‐mimetic assembly strategy, with Peptide‐AptCD63 conjugates acting as antibody surrogates binding CD63 epitopes on mesenchymal stem cell‐derived exosomes. This creates a hierarchical microstructure intended to synergistically integrate antioxidative and anti ...
Dantong Zheng, Yuxin Bai, Zhibo Liu, Zinan Zhao, Yiming Kong, Yao Xu, Qi Jia, Rongrong Zhu, Yong Hu   +8 more
wiley   +1 more source

Ten Foundational Principles in Hand Surgery: A Primer for Orthopedic Practice. [PDF]

J Orthop Case Rep
Pai SN, Rajappa S, Jeyaraman M, Shyam A.
europepmc   +1 more source