Results 91 to 100 of about 419,755 (313)

Use of Bisphosphonates in Orthopedic Surgery: Pearls and Pitfalls

, 2014
Bisphosphonates are medications known to decrease bone resorption by inhibiting osteoclastic activity. They are the first-line therapy for the treatment of osteoporosis because a significant body of literature has proved their efficacy in reducing the ...
Raskin, Kevin A., Colman, Matthew W., Hornicek, Francis J., Gebhardt, Mark, Lozano-Calderon, Santiago A.   +4 more
core   +1 more source

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

Prosthetic Loosening in a Total Hip Arthroplasty Patient After Breast Cancer Chemotherapy and Hormonal Therapy: A Case Report

Drug, Healthcare and Patient Safety
Jiemin Li,1,* Shixun Li,2,* Changchuan Li,2 Zhong Chen,2 Yue Ding2 1Department of Nurse Administration, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 2Department of Orthopaedic ...
Li J, Li S, Li C, Chen Z, Ding Y
doaj  

Exploring the impact of pathogenic microbiome in orthopedic diseases: machine learning and deep learning approaches

Frontiers in Cellular and Infection Microbiology
Osteoporosis, arthritis, and fractures are examples of orthopedic illnesses that not only significantly impair patients’ quality of life but also complicate and raise the expense of therapy. It has been discovered in recent years that the pathophysiology
Zhuce Shao, Huanshen Gao, Benlong Wang, Shenqi Zhang   +3 more
doaj   +1 more source

Disorders Leading to Early-Onset Osteoarthritis: Orthopedic Considerations and Insights

Osteoarthritis (OA), characterized by articular cartilage deterioration, is influenced by factors such as age, trauma, genetic alterations, and inflammatory diseases. Early-onset osteoarthritis (EO-OA), typically observed before 40 or 50, can result from
Ahmet Issın, ISSIN, AHMET, ISSIN, GİZEM, Gizem Issın   +3 more
core   +1 more source

Deconstruction of Human Age‐Related Cataract Capsules Defines Aging

Advanced Science, EarlyView.
We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang, Ziyang Tong, Chunmei Fan, Silong Chen, Jiarui Guo, Jianghua Hu, Ke Yao, Zi Yin, Xiao Chen, Yibo Yu   +9 more
wiley   +1 more source

Advances in the Role of Stem Cell-Derived Exosomes in Diabetic Foot Wound Healing

Diabetes, Metabolic Syndrome and Obesity
Junbo Wang,1 Yu-Jie Liang,2 Xiaohua Pan1 1Department of Orthopaedics and Traumatology, The Second Affiliated Hospital of Shenzhen University, Shenzhen, People’s Republic of China; 2The Chinese University of Hong Kong, Hong Kong, People’s Republic of ...
Wang J, Liang YJ, Pan X
doaj  

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

Advanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han, Yao Zhao, Chengbo Yang, Miao Niu, Jun Dai, Quanxin Ning, Kai Xiao, Jinzheng Liang, Wensheng Zhang, Liang Wang, Dan Shao, Dongsong Li   +11 more
wiley   +1 more source

Home Rehabilitation Experience and Influencing Factors in Frail Elderly Patients with Lumbar Spine Surgery: A Qualitative Study

Patient Preference and Adherence
Wei Jiang,1,* Mingyang Qian,1,* Qingsong Zou,1 Xiaowei Chen,2 Mengyi Xu,3 Jiangming Yu3 1Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu Province, 214122, People’s Republic of China; 2Kunshan Hospital of Traditional Chinese ...
Jiang W, Qian M, Zou Q, Chen X, Xu M, Yu J   +5 more
doaj  

Surgical site infections in treatment of musculoskeletal tumors: experience from a single oncologic orthopedic institution [PDF]

, 2016
Objective: Limb-sparing surgery is the mainstay treatment for musculoskeletal tumors thanks to advances in surgical techniques, imaging modalities and multimodal therapies.
Biagini R, Ferraresi V, Rossi B, Toma L, Zoccali C   +4 more
core   +1 more source