Results 71 to 80 of about 419,755 (313)

A new structural method permits the evaluation of bone quality and fracture risk in a case of rapid and progressive osteoporosis of the hand (CRPS type II)

, 2013
Aims Even if densitometry is still currently considered to be the gold standard in bone quality assessment, however, the medical community has long been aware that two are the factors that increase bone weakness: bone mineralization loss and micro ...
COSMI, Francesca, Mazzoleni Giovanna, Attanasio Marco, Steimberg Nathalie   +3 more
core  

Stage‐Adaptive Janus Microneedle System for Redox‐Immune Regulation and Mitochondrial Protection in Infected Diabetic Wound Healing

Advanced Science, EarlyView.
ABSTRACT Infected diabetic wounds are sustained by a vicious cycle of hyperglycemia‐driven bacterial infection, persistent oxidative stress, and excessive inflammation, which collectively disrupt the ordered progression of tissue repair. Here, we engineered a stage‐adaptive Janus microneedle patch (MN‐FeSAC‐PPE) to enable a staged therapeutic process ...
Mengting Yin, Yu Zhang, Xinyu Qu, Jiayi Liu, Zhongyi Sun, Haibo Liu, Ziyan Chen, Jing Ru, Jingwen Han, Bingqiang Lu, Yan Lu, Yan Wang, Xinyu Zhao, Feng Chen   +13 more
wiley   +1 more source

Environmental noise as risk factor for postoperative delirium in an orthopedic sample: an exploratory, correlational study [PDF]

, 2013
Postoperative delirium (PD) affects approximately 25 percent of participants over the age of 60 having major surgery. Long term negative effects include persistent delirium, loss of independence, nursing home placement, and mortality.
Brown, Courtney, NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

Nanostructured selenium for anti-cancer orthopedic applications

, 2008
Current orthopedic implants have numerous problems that include poor osseointegration, stress shielding and wear debris-associated bone cell death. In particular, certain metallic implants slowly generate corrosion products that limit their performance ...
Tran, Phong, Webster, Thomas J.
core   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Gut Microbiota and Tryptophan Metabolism as Therapeutic Targets for Spinal Cord Injury: Insights From Probiotic Treatment

Journal of Inflammation Research
Jinwang Dong,1,2,* Chen Xu,1,* Shanshan Jin,3,* Tao Xie,1,* Zhengwei Xu,1 Dingjun Hao,1 Liang Dong1 1Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China ...
Dong J, Xu C, Jin S, Xie T, Xu Z, Hao D, Dong L   +6 more
doaj  

The Surprising Effect of Body Mass Index on Elective Orthopedic Surgeries

The Journal of the International Society of Physical and Rehabilitation Medicine, 2019
Elective orthopedic surgeries are often deferred or declined due to concern about the patient's elevated body mass index (BMI). The study team conducted a literature review of studies focusing on the relationship between BMI and outcomes of elective ...
David T Burke, Regina B Bell, Daniel P Burke   +2 more
doaj   +1 more source

Novel anti-cancer orthopedic materials: Nanostructured selenium

, 2007
Metallic bone implants possess numerous problems limiting their efficacy, such as poor osseointegration, stress shielding, and corrosion in in vivo environments.
Tran, Phong A., Phong Tran, Thomas J. Webster, Webster, Thomas J.   +3 more
core   +1 more source

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, EarlyView.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

Analysis of Risk Factors for Postoperative Complications of Thoracolumbar Brucella Spondylitis

Infection and Drug Resistance
Yao Zhang,1 Changsong Zhao,1 Jiamin Chen,2 Qiang Zhang1 1Department of Orthopedics, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People’s Republic of China; 2Department of Pathology, Beijing Ditan Hospital, Capital Medical ...
Zhang Y, Zhao C, Chen J, Zhang Q
doaj