Results 81 to 90 of about 342,595 (268)

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

Experimental model of a bone gap by radial ostectomy in rabbits [PDF]

Biotemas, 2010
A lot of experimental models have been used to study the process of a fracture’s consolidation, but the problem is that due to anatomic, biologic and technical differences, these models do not always have appropriate parameters for the exact species, for
Antonio Carlos Cunha Lacreta Junior, Everton Regonato, Lucas Bahdour Cossi, Ciro Alexandre Teixeira Cruvinel, Júlio Carlos Canola   +4 more
doaj  

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Postoperative management following equine orthopedic surgery: a survey of diplomates of the ACVS and ACVSMR

Frontiers in Veterinary Science
Postoperative management, including rehabilitation and physical therapy, is important to decrease pain and improve return to function in human and small animal orthopedic surgical cases; however, recommendations for postoperative management for equine ...
Carrie Jacobs, Lauren Virginia Schnabel, Caitlyn Redding Horne, Sara Tufts, Emily Gray Medlin Martin, Kim Love   +5 more
doaj   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

CD31+ Cell Enrichment Enhances Therapeutic Effects of Stromal Vascular Fraction in Experimental Primary Osteoarthritis: A Preclinical Study in the Dunkin Hartley Guinea Pig Model

Advanced Science, EarlyView.
Both SVF and CD31+ SVF improve spontaneous osteoarthritis, but CD31+ enrichment refines the therapeutic profile rather than broadly enhancing all effects. More distinct benefits are observed in extracellular matrix remodeling, osteochondral integrity, and subchondral/trabecular bone preservation, supporting CD31+‐enriched SVF as a biologically enhanced
Sijia Zhou, Tobias Winkler, Bin Chen, Marta Grzeski, Yilong Yang, Florian N. Fleckenstein, Dominik Geisel, Alexander Hildebrandt, Daniela Aschenbrenner, Marie Agatha Mohn, Benjamin Claass, January Weiner 3rd, Sven Geissler, Georg N. Duda, Søren P. Sheikh, Oliver Klein, Tazio Maleitzke   +16 more
wiley   +1 more source

Compliance Towards Infection Prevention and Control Practices in Orthopedic Department of a Tertiary Care Hospital

Online Journal of Health & Allied Sciences, 2019
The aim of was to analyzing the infection control practices in the Orthopedic department of a tertiary care hospital of South India. Methods: A total of 535 events were observed using structured observation checklist through participatory observation in ...
Latha T, Anil K Bhat, Manjunatha Hande, Chiranjay Mukhopadhyay, Elsa Sanatombi Devi, Baby S Nayak, Anice George   +6 more
doaj  

Advancements in Orthopedic Implants: A Comprehensive Review of Selective Laser Melting Technology in Manufacturing Human Prosthetics

Düzce Üniversitesi Bilim ve Teknoloji Dergisi
The advancement of Additive Manufacturing (AM) technologies, particularly Selective Laser Melting (SLM), has significantly influenced the development of orthopedic, dental, and spinal implants.
Yasemin Tabak, Omid Ashkani, Salar Hashemi Nasab, Rojin Hamsian Etefagh, Arian Bazmi, Shahram Mahboubizadeh   +5 more
doaj   +1 more source

The future of orthopedics

Journal of Orthopaedic Science, 2009
Just as fi ctional stories, such as 1984 by George Orwell and Our Posthuman Future by Francis Fukuyama, have not accurately portrayed the future of the human race, predictions about the future of orthopedics made during past years have seldom become a reality.
openaire   +2 more sources