Results 61 to 70 of about 343,106 (269)

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Bioinformatics and Experimental Validation of FLVCR1 and SOX4 in Regulating Mitochondria-Macrophage Crosstalk in Disc Degeneration

Journal of Inflammation Research
Ji Zhou,1 Yang Zheng,2 Xie Zheng,1 Chun-yan Chen,1 Su-cheng Ding,1 Rong Wang1 1People’s Hospital of Anji, Huzhou, People’s Republic of China; 2The Department of Orthopedics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou ...
Zhou J, Zheng Y, Zheng X, Chen CY, Ding SC, Wang R   +5 more
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Exploring the impact of pathogenic microbiome in orthopedic diseases: machine learning and deep learning approaches

Frontiers in Cellular and Infection Microbiology
Osteoporosis, arthritis, and fractures are examples of orthopedic illnesses that not only significantly impair patients’ quality of life but also complicate and raise the expense of therapy. It has been discovered in recent years that the pathophysiology
Zhuce Shao, Huanshen Gao, Benlong Wang, Shenqi Zhang   +3 more
doaj   +1 more source

A challenging management of hemophilia B patient with inhibitors undergoing major orthopedic surgeries in a resource‐constrained country

Clinical Case Reports, 2020
In this paper, we report a life‐threatening condition and relate our experience in managing a hemophilia B patient who required three surgical procedures, highlighting the difficulties we encountered in our setting and propose some tangible.
Wafaa Matrane, Afak Nsiri, Mohamed Rafai, Fatima Midmani, Nada Boughaza, Siham Cherkaoui, Meryem Qachouh, Nisrine Khoubila   +7 more
doaj   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Prosthetic Loosening in a Total Hip Arthroplasty Patient After Breast Cancer Chemotherapy and Hormonal Therapy: A Case Report

Drug, Healthcare and Patient Safety
Jiemin Li,1,* Shixun Li,2,* Changchuan Li,2 Zhong Chen,2 Yue Ding2 1Department of Nurse Administration, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 2Department of Orthopaedic ...
Li J, Li S, Li C, Chen Z, Ding Y
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Stage‐Adaptive Janus Microneedle System for Redox‐Immune Regulation and Mitochondrial Protection in Infected Diabetic Wound Healing

Advanced Science, EarlyView.
ABSTRACT Infected diabetic wounds are sustained by a vicious cycle of hyperglycemia‐driven bacterial infection, persistent oxidative stress, and excessive inflammation, which collectively disrupt the ordered progression of tissue repair. Here, we engineered a stage‐adaptive Janus microneedle patch (MN‐FeSAC‐PPE) to enable a staged therapeutic process ...
Mengting Yin, Yu Zhang, Xinyu Qu, Jiayi Liu, Zhongyi Sun, Haibo Liu, Ziyan Chen, Jing Ru, Jingwen Han, Bingqiang Lu, Yan Lu, Yan Wang, Xinyu Zhao, Feng Chen   +13 more
wiley   +1 more source

Advances in the Role of Stem Cell-Derived Exosomes in Diabetic Foot Wound Healing

Diabetes, Metabolic Syndrome and Obesity
Junbo Wang,1 Yu-Jie Liang,2 Xiaohua Pan1 1Department of Orthopaedics and Traumatology, The Second Affiliated Hospital of Shenzhen University, Shenzhen, People’s Republic of China; 2The Chinese University of Hong Kong, Hong Kong, People’s Republic of ...
Wang J, Liang YJ, Pan X
doaj  

An Energy Autonomous Microneedle Array‐Based Sensing System for Continuous Biomarker Monitoring

Advanced Science, EarlyView.
This work presents an innovative self‐powered wearable biosensor system for real‐time monitoring of multiple biomarkers in interstitial fluid. The device integrates stainless steel‐based minimally invasive microneedles with ion‐selective membranes, enabling simultaneous Na+, K+, Ca2+, pH, and glucose detection.
Arnab Pal, Kai‐Po Fan, Sheng‐Chun Hung, Jaba Roy Chowdhury, Jun‐Hsun Chung, Meenakshi Ray, Hsiang‐Yun Hsu, Fu‐Cheng Kao, Kuei‐Lin Liu, Zong‐Hong Lin   +9 more
wiley   +1 more source

Home Rehabilitation Experience and Influencing Factors in Frail Elderly Patients with Lumbar Spine Surgery: A Qualitative Study

Patient Preference and Adherence
Wei Jiang,1,* Mingyang Qian,1,* Qingsong Zou,1 Xiaowei Chen,2 Mengyi Xu,3 Jiangming Yu3 1Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu Province, 214122, People’s Republic of China; 2Kunshan Hospital of Traditional Chinese ...
Jiang W, Qian M, Zou Q, Chen X, Xu M, Yu J   +5 more
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