Results 51 to 60 of about 358,617 (267)

Analysis of Risk Factors for Postoperative Complications of Thoracolumbar Brucella Spondylitis

Infection and Drug Resistance
Yao Zhang,1 Changsong Zhao,1 Jiamin Chen,2 Qiang Zhang1 1Department of Orthopedics, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People’s Republic of China; 2Department of Pathology, Beijing Ditan Hospital, Capital Medical ...
Zhang Y, Zhao C, Chen J, Zhang Q
doaj  

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Integration of nefopam into the postoperative multimodal analgesia protocol in orthopedic and trauma surgery - Batna university hospital [PDF]

Batna Journal of Medical Sciences
Introduction and Objectives. Nefopam is a non-opioid central analgesic commonly employed in perioperative multimodal analgesia protocols due to its intrinsic antinociceptive properties.
Ouarda GUERZA, Hanane BENALDJIA, Fadila FELOUAT   +2 more
doaj   +1 more source

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Prosthetic Loosening in a Total Hip Arthroplasty Patient After Breast Cancer Chemotherapy and Hormonal Therapy: A Case Report

Drug, Healthcare and Patient Safety
Jiemin Li,1,* Shixun Li,2,* Changchuan Li,2 Zhong Chen,2 Yue Ding2 1Department of Nurse Administration, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, People’s Republic of China; 2Department of Orthopaedic ...
Li J, Li S, Li C, Chen Z, Ding Y
doaj  

A challenging management of hemophilia B patient with inhibitors undergoing major orthopedic surgeries in a resource‐constrained country

Clinical Case Reports, 2020
In this paper, we report a life‐threatening condition and relate our experience in managing a hemophilia B patient who required three surgical procedures, highlighting the difficulties we encountered in our setting and propose some tangible.
Wafaa Matrane, Afak Nsiri, Mohamed Rafai, Fatima Midmani, Nada Boughaza, Siham Cherkaoui, Meryem Qachouh, Nisrine Khoubila   +7 more
doaj   +1 more source

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source

Bioinformatics and Experimental Validation of FLVCR1 and SOX4 in Regulating Mitochondria-Macrophage Crosstalk in Disc Degeneration

Journal of Inflammation Research
Ji Zhou,1 Yang Zheng,2 Xie Zheng,1 Chun-yan Chen,1 Su-cheng Ding,1 Rong Wang1 1People’s Hospital of Anji, Huzhou, People’s Republic of China; 2The Department of Orthopedics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou ...
Zhou J, Zheng Y, Zheng X, Chen CY, Ding SC, Wang R   +5 more
doaj  

Exploring the impact of pathogenic microbiome in orthopedic diseases: machine learning and deep learning approaches

Frontiers in Cellular and Infection Microbiology
Osteoporosis, arthritis, and fractures are examples of orthopedic illnesses that not only significantly impair patients’ quality of life but also complicate and raise the expense of therapy. It has been discovered in recent years that the pathophysiology
Zhuce Shao, Huanshen Gao, Benlong Wang, Shenqi Zhang   +3 more
doaj   +1 more source