Results 81 to 90 of about 344,168 (268)

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

Experimental model of a bone gap by radial ostectomy in rabbits [PDF]

Biotemas, 2010
A lot of experimental models have been used to study the process of a fracture’s consolidation, but the problem is that due to anatomic, biologic and technical differences, these models do not always have appropriate parameters for the exact species, for
Antonio Carlos Cunha Lacreta Junior, Everton Regonato, Lucas Bahdour Cossi, Ciro Alexandre Teixeira Cruvinel, Júlio Carlos Canola   +4 more
doaj  

Deconstruction of Human Age‐Related Cataract Capsules Defines Aging

Advanced Science, EarlyView.
We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang, Ziyang Tong, Chunmei Fan, Silong Chen, Jiarui Guo, Jianghua Hu, Ke Yao, Zi Yin, Xiao Chen, Yibo Yu   +9 more
wiley   +1 more source

Postoperative management following equine orthopedic surgery: a survey of diplomates of the ACVS and ACVSMR

Frontiers in Veterinary Science
Postoperative management, including rehabilitation and physical therapy, is important to decrease pain and improve return to function in human and small animal orthopedic surgical cases; however, recommendations for postoperative management for equine ...
Carrie Jacobs, Lauren Virginia Schnabel, Caitlyn Redding Horne, Sara Tufts, Emily Gray Medlin Martin, Kim Love   +5 more
doaj   +1 more source

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

Advanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han, Yao Zhao, Chengbo Yang, Miao Niu, Jun Dai, Quanxin Ning, Kai Xiao, Jinzheng Liang, Wensheng Zhang, Liang Wang, Dan Shao, Dongsong Li   +11 more
wiley   +1 more source

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Compliance Towards Infection Prevention and Control Practices in Orthopedic Department of a Tertiary Care Hospital

Online Journal of Health & Allied Sciences, 2019
The aim of was to analyzing the infection control practices in the Orthopedic department of a tertiary care hospital of South India. Methods: A total of 535 events were observed using structured observation checklist through participatory observation in ...
Latha T, Anil K Bhat, Manjunatha Hande, Chiranjay Mukhopadhyay, Elsa Sanatombi Devi, Baby S Nayak, Anice George   +6 more
doaj  

Advancements in Orthopedic Implants: A Comprehensive Review of Selective Laser Melting Technology in Manufacturing Human Prosthetics

Düzce Üniversitesi Bilim ve Teknoloji Dergisi
The advancement of Additive Manufacturing (AM) technologies, particularly Selective Laser Melting (SLM), has significantly influenced the development of orthopedic, dental, and spinal implants.
Yasemin Tabak, Omid Ashkani, Salar Hashemi Nasab, Rojin Hamsian Etefagh, Arian Bazmi, Shahram Mahboubizadeh   +5 more
doaj   +1 more source

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

Clinical Study on the Effects of Total Hip Arthroplasty Assisted by Virtual Planning Combined With Intraoperative Navigation Templates

Orthopaedic Surgery
Objectives Although total hip arthroplasty (THA) effectively alleviates pain and restores joint function in the end‐stage hip disease, challenges remain in achieving precise osteotomy and minimizing subjective dependency on prosthesis positioning.
Haotian Zhu, Jiayi Wu, Kai Cheng, Han Yan, Junjun Liang, Yunjin Long, Shaoxing Fan, Yadi Zhang, Huanwen Ding   +8 more
doaj   +1 more source