Results 61 to 70 of about 342,595 (268)

Bioinformatics and Experimental Validation of FLVCR1 and SOX4 in Regulating Mitochondria-Macrophage Crosstalk in Disc Degeneration

Journal of Inflammation Research
Ji Zhou,1 Yang Zheng,2 Xie Zheng,1 Chun-yan Chen,1 Su-cheng Ding,1 Rong Wang1 1People’s Hospital of Anji, Huzhou, People’s Republic of China; 2The Department of Orthopedics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou ...
Zhou J, Zheng Y, Zheng X, Chen CY, Ding SC, Wang R   +5 more
doaj  

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Gut Microbiota and Tryptophan Metabolism as Therapeutic Targets for Spinal Cord Injury: Insights From Probiotic Treatment

Journal of Inflammation Research
Jinwang Dong,1,2,* Chen Xu,1,* Shanshan Jin,3,* Tao Xie,1,* Zhengwei Xu,1 Dingjun Hao,1 Liang Dong1 1Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China ...
Dong J, Xu C, Jin S, Xie T, Xu Z, Hao D, Dong L   +6 more
doaj  

Exploring the impact of pathogenic microbiome in orthopedic diseases: machine learning and deep learning approaches

Frontiers in Cellular and Infection Microbiology
Osteoporosis, arthritis, and fractures are examples of orthopedic illnesses that not only significantly impair patients’ quality of life but also complicate and raise the expense of therapy. It has been discovered in recent years that the pathophysiology
Zhuce Shao, Huanshen Gao, Benlong Wang, Shenqi Zhang   +3 more
doaj   +1 more source

A challenging management of hemophilia B patient with inhibitors undergoing major orthopedic surgeries in a resource‐constrained country

Clinical Case Reports, 2020
In this paper, we report a life‐threatening condition and relate our experience in managing a hemophilia B patient who required three surgical procedures, highlighting the difficulties we encountered in our setting and propose some tangible.
Wafaa Matrane, Afak Nsiri, Mohamed Rafai, Fatima Midmani, Nada Boughaza, Siham Cherkaoui, Meryem Qachouh, Nisrine Khoubila   +7 more
doaj   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Analysis of Risk Factors for Postoperative Complications of Thoracolumbar Brucella Spondylitis

Infection and Drug Resistance
Yao Zhang,1 Changsong Zhao,1 Jiamin Chen,2 Qiang Zhang1 1Department of Orthopedics, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, People’s Republic of China; 2Department of Pathology, Beijing Ditan Hospital, Capital Medical ...
Zhang Y, Zhao C, Chen J, Zhang Q
doaj  

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

Advances in the Role of Stem Cell-Derived Exosomes in Diabetic Foot Wound Healing

Diabetes, Metabolic Syndrome and Obesity
Junbo Wang,1 Yu-Jie Liang,2 Xiaohua Pan1 1Department of Orthopaedics and Traumatology, The Second Affiliated Hospital of Shenzhen University, Shenzhen, People’s Republic of China; 2The Chinese University of Hong Kong, Hong Kong, People’s Republic of ...
Wang J, Liang YJ, Pan X
doaj  

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source