Results 101 to 110 of about 419,755 (313)

The IRE1‐XBP1s Axis Drives Inflammatory Osteolysis by Regulating a 5‐HT Dependent Endogenous Anti‐Autophagy Mechanism

Advanced Science, EarlyView.
A previously unrecognized IRE1‐XBP1s‐Slc6a4 signaling axis links endoplasmic reticulum stress to serotonin metabolism, autophagy, and inflammatory osteoclastogenesis. By promoting intracellular serotonin uptake and reducing endogenous 3‐methyladenine accumulation, this pathway accelerates inflammatory bone destruction and provides a promising ...
Pengchao Yang, Binxiang Zhu, Yuzhi He, Yang Tian, Honglei Kang, Shian Hu, Pengju Wang, Yong Xu, Zhuowei Lei, Peijun Qi, Hao Yang, Yang Lin, Yimin Dong, Feng Li, Hanfeng Guan   +14 more
wiley   +1 more source

Biomimetic Barium Titanate/PLA Scaffold with Shape Memory and Bioelectro-Active Capacities Promotes Bone Regeneration

International Journal of Nanomedicine
Shiyan Lv,1,* Yuechi Zhang,2,* Xiongjie Liang,1,* Wenbo Xu,1 Zhibin Geng,1 Weifeng Hu,1 Xiaoyan Wang,1 Helin Li,1 Wenhui Guo,1 Yongbin Jing,1 Xiaoqi Liu,1 Huichao Fu,1 Gongping Xu,1 Chunyang Xi,1 Jinglong Yan,1 Hui Chi1 ...
Lv S, Zhang Y, Liang X, Xu W, Geng Z, Hu W, Wang X, Li H, Guo W, Jing Y, Liu X, Fu H, Xu G, Xi C, Yan J, Chi H   +15 more
doaj  

Socioeconomic value of orthopedic devices: evidence and methodological challenges

, 2012
Corinna Sorenson,1,2 Michael Drummond2,31LSE Health, London School of Economics, London, UK; 2European Health Technology Institute for Socioeconomic Research, Brussels, Belgium; 3Centre for Health Economics, University of York, York, UKAbstract: With ...
Sorenson C, Drummond M
core  

A High‐Loading Zn Single‐Atom Nanozyme Targets the Zn/HIF‐1α/GLUT1 Axis to Disrupt Glucose Metabolic Reprogramming and Remodel the Tumor Immune Microenvironment

Advanced Science, EarlyView.
A high‐loading Zn single‐atom nanozyme (ZMG@CS) delivers ML‐SA5 and GOx to lysosomes. ML‐SA5 activates TRPML1 to release endogenous Zn2+, while the nanozyme provides exogenous Zn2+ and GOx‐driven acidification amplifies ROS production. Together, these effects suppress the HIF‐1α/GLUT1 axis, disrupt glucose and redox homeostasis, induce disulfidptosis ...
Zhenxin Wang, Yuhang Tang, Ronghao Yue, Jingtao Xu, Yong Tao, Jie Chen, Shipeng Li, Guosheng Zhao, Jinfang Xue, Mingwei Sun, Fenglei Gao, Yunsheng Ou, Yang Wang   +12 more
wiley   +1 more source

Multimodal Synergistic Strategies for Diabetic Wound Healing Using Glucose Oxidase Nanocomposites: Therapeutic Mechanisms and Nanomaterial Design

International Journal of Nanomedicine
Zaiwei Fan,1,* Chengzhi Liang,1,* Jiayu Zhang,2,* Yiming Li,3,* Lihua Tan,1 Hui Deng,1 Pinkai Wang,1 Jialiang Wang,1 Jiawei Kang,1 Yudan Zhu,1 Hang Fu,1 Jun Tao1 1Department of Orthopedics, The Second Affiliated Hospital ...
Fan Z, Liang C, Zhang J, Li Y, Tan L, Deng H, Wang P, Wang J, Kang J, Zhu Y, Fu H, Tao J   +11 more
doaj  

Progress in Dentin-Derived Bone Graft Materials: A New Xenogeneic Dentin-Derived Material with Retained Organic Component Allows for Broader and Easier Application

Cells
The optimal repair of rigid mineralized tissues, such as bone, in cases of fracture, surgical resection, or prosthetic placement, is a complex process often necessitating the use of bone graft materials.
Lari Sapoznikov, Martin Humphrey
doaj   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Vitamin E Protects Against Gestational Deep Vein Thrombosis: The Role of Inhibiting Endothelial Ferroptosis

Drug Design, Development and Therapy
Junrong Zhang,1,* Rong Du,1,* Weiwei Sun,2,* Yan Huang,1 You Zhang,1 Kuleman Bayibieke,1 Lu Chen,3 Tingting Lu,4 Huihua Ni,1 Xiuli Zhong,1 Chen Chen,1 Baolan Sun,5 Yunzhao Xu,1 Xi Cheng11Department of Gynecology and Obstetrics ...
Zhang J, Du R, Sun W, Huang Y, Zhang Y, Bayibieke K, Chen L, Lu T, Ni H, Zhong X, Chen C, Sun B, Xu Y, Cheng X   +13 more
doaj  

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source

The future of orthopedics

Journal of Orthopaedic Science, 2009
Just as fi ctional stories, such as 1984 by George Orwell and Our Posthuman Future by Francis Fukuyama, have not accurately portrayed the future of the human race, predictions about the future of orthopedics made during past years have seldom become a reality.
openaire   +2 more sources