Results 101 to 110 of about 1,705,353 (309)

Osteopathic Student Matriculation Trends in Surgical Subspecialties (2016-2024): A Systematic Review

Journal of Medical Education and Curricular Development
Background There is a paucity of data on trends of osteopathic medical students (OMS) matriculating into surgical specialties since the installation of the single U.S.
Bridgette Kielhack, Selena K. Cholak, Virgil K. DeMario, Vaishnavi J. Patel, Devki Patel, Kimberly Toumazos, Mark Quiring, Young Son, John Etlinger   +8 more
doaj   +1 more source

ORTHOPEDIC SURGERY IN THE AGING POPULATION: CHALLENGES AND FUTURE DIRECTIONS

Tạp chí Sức khỏe và Lão hóa (Journal of Health and Aging)
The rapid aging of the global population has led to a substantial rise in the demand for orthopedic surgery among elderly patients, particularly for hip, knee, and shoulder arthroplasty.
Tran Quoc Doanh, Ho Bui Dieu Linh, Tran Khoi Luan, Vu Quoc Hung, Nguyen Van Binh, Tran Duc Tai, Dang Thi Hai An, Doan Van Khue, Le My Huyen, Nguyen Anh Sang   +9 more
doaj   +1 more source

Dual‐Gene Edited Extracellular Vesicles Remodel the Redox Homeostasis to Inhibit Ferroptosis in Intervertebral Disc Degeneration

Advanced Science, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is driven by ferroptosis of nucleus pulposus cells (NPCs) as a core pathological mechanism. Nucleus pulposus progenitor cells (NPPCs), exhibiting stem cell‐like properties, yield extracellular vesicles (PEVs) with high affinity for NPCs and enable targeted phenotypic regulation.
Jing Yan, Yazhou Lin, Shuo Miao, Minghao Chao, Chengbai Dai, Ziwen Hao, Rui Chen, Ming Guan, Bin Pan, Fenglei Gao, Quan Zhou   +10 more
wiley   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Use of Bisphosphonates in Orthopedic Surgery: Pearls and Pitfalls

, 2014
Bisphosphonates are medications known to decrease bone resorption by inhibiting osteoclastic activity. They are the first-line therapy for the treatment of osteoporosis because a significant body of literature has proved their efficacy in reducing the ...
Raskin, Kevin A., Colman, Matthew W., Hornicek, Francis J., Gebhardt, Mark, Lozano-Calderon, Santiago A.   +4 more
core   +1 more source

Factors influencing the selection criteria of Saudi board orthopedic surgery applicants: a national survey of program directors

BMC Medical Education
Background Annually, medical students vie to secure a seat with an orthopedic residency program. This rigorous competition places orthopedic surgery as one of the most competitive specialties in the medical field.
Suhail S. AlAssiri, Alwaleed A. Alshahir, Sami I. Al Eissa, Fahad H. Al Helal, Faisal M Konbaz, Majed S. Abaalkhail, Rayed M. Al Jehani, Abdullah F. Mohabbat, Khalid A. AlSheikh   +8 more
doaj   +1 more source

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source

Incidence of perioperative hypothermia in orthopaedic surgery and risk factors

Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2016
Purpose: The purpose of this research is to determine the incidence with causing factors such as demographic characteristics, type of surgery, type of anesthesia, operation time and operating room temperature of hypothermia during perioperative period of
Ayfer Yurdadur Duman, Emel Yilmaz
doaj   +1 more source

Aprotinin and major orthopedic surgery [PDF]

Transfusion Alternatives in Transfusion Medicine, 2004
SUMMARYAprotinin is a potent pharmacological agent which reduces bleeding and limits blood transfusion in current surgical practice. Many studies have been conducted in orthopedic surgery. Several trials have been performed in total hip replacement and total knee replacement patients, and aprotinin only moderately decreased blood loss requirements in ...
openaire   +2 more sources

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source