Results 181 to 190 of about 360,787 (305)

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Provincial agreements for pregnant and parenting orthopedic surgery residents: a call for a national residency guideline. [PDF]

Can J Surg
Morrison LJ, Abbott AG, Barton KI, Thibaudeau P, Hiemstra L.   +4 more
europepmc   +1 more source

Overcoming transfusion-refractory anemia: partial splenic embolization to facilitate orthopedic surgery in β-thalassemia. [PDF]

Ann Hematol
Ye QQ, Zhou XG, Yang G, Xie WT, Yu AY, Duan HZ.   +5 more
europepmc   +1 more source

Optimizing biophysical properties of cellular niches to enhance stem cell‐derived extracellular vesicle function in musculoskeletal regeneration

BMEMat, EarlyView.
Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu, Chung Yin Matthew Cheung, Liling Liu, Hoi Pan Harry Cheung, Kam Yu Tam, Dai Fei Elmer Ker, Sarah H. Cartmell, Chuanbin Mao, Zhiyong Zhang, Dan Michelle Wang   +9 more
wiley   +1 more source

Renal safety of intraoperative local vancomycin powder application in orthopedic surgery: a retrospective analysis. [PDF]

J Bone Jt Infect
Beschauner J, Felsberg M, Zeh A, Delank KS, Gutteck N, Werneburg F.   +5 more
europepmc   +1 more source

Morphological Analysis of the Latissimus Dorsi Tendon Insertion: Implications for Optimizing Tendon Transfer Surgeries in Rotator Cuff Repair

Clinical Anatomy, EarlyView.
ABSTRACT Latissimus dorsi (LD) tendon transfer is widely used to treat irreparable rotator cuff tears, particularly in cases with posterosuperior and anterosuperior tear patterns. We conducted a comprehensive anatomical analysis of the attachment of the LD tendon to the humerus, focusing on its morphological patterns and morphometric features, which ...
Sehyun Kwon, Chang Hyuk Choi, Hongtae Kim, Mi‐Sun Hur   +3 more
wiley   +1 more source

Postoperative management following equine orthopedic surgery: a survey of diplomates of the ACVS and ACVSMR. [PDF]

Front Vet Sci
Jacobs C, Schnabel LV, Redding Horne C, Tufts S, Martin EGM, Love K.   +5 more
europepmc   +1 more source

Advancing Maternal Health with Long‐Acting Therapeutics: Priorities, Efficacy and Safety Considerations, and Emerging Technologies

Clinical Pharmacology &Therapeutics, EarlyView.
Maternal health remains a critical global concern, particularly in underserved populations and in low‐ and middle‐income countries where access to safe and effective therapeutics is limited. Despite the use of medications by most women during pregnancy, the exclusion of pregnant and lactating women from clinical trials has resulted in significant data ...
Rachel K. Scott, Sharon Nachman, Ethel D. Weld, Rachel Daley, Shakir Atoyebi, Robert Bies, Catriona Waitt, Adeniyi Olagunju   +7 more
wiley   +1 more source

Rethinking venous thromboembolism risk after major orthopedic surgery: a transient threat or a persistent problem? [PDF]

Res Pract Thromb Haemost
Story CM, Merz LE, Schaefer JK.
europepmc   +1 more source

Orthopedic surgery [PDF]

Arthritis & Rheumatism, 1981
openaire   +1 more source