Results 221 to 230 of about 360,787 (305)

Arp2/3 complex and β1 integrin drive an invasive front through extracellular matrix adaptation in pancreatic cancer

International Journal of Cancer, EarlyView.
What's New? Pancreatic ductal adenocarcinoma is characterized by a dense extracellular matrix, and how invasive tumor cells overcome such biomechanical constraints remains unclear. This study identifies the actin‐related protein 2/3 complex as a key regulator of pancreatic ductal adenocarcinoma invasiveness, driving fibroblast migration through β1 ...
Xiufen Yang, Yina Qiao, Yifeng Sun, Tamer Abdelaal, Kathleen Schuck, Hend Abdelrasoul, Carolina De La Torre, Malte Hermes, Yan Dong, Jingxiong Hu, Chao Fang, Xiaoyan Huang, Christoph Kahlert, Ingrid Herr, Christoph W. Michalski, Bo Kong   +15 more
wiley   +1 more source

Does perioperative discontinuation of anti-rheumatic drugs increase postoperative complications in orthopedic surgery for rheumatoid arthritis? [PDF]

Arthritis Res Ther
Ito H, Ishikawa H, Tsuji S, Nakayama M, Nishida K, Mochizuki T, Ebina K, Kojima T, Matsumoto T, Kubota A, Nakajima A, Kaneko A, Matsushita I, Hara R, Sakuraba K, Akasaki Y, Matsubara T, Mochida Y, Kanbe K, Nakagawa N, Murata K, Momohara S.   +21 more
europepmc   +1 more source

Pyridoxal Reprograms Peroxisomal Hydrogen Peroxide Metabolism to Induce Lethal Oxidative Stress in Ovarian Cancer

iMetaMed, EarlyView.
Pyridoxal (PL) exhibits the strongest anti‐tumor activity within the vitamin B6 family, demonstrating significant ovarian cancer cell‐killing efficacy in vivo, in vitro, and in patient‐derived organoid (PDO) models. The anti‐tumor mechanism involves PL inducing a shift in peroxisome dynamics towards fission, promoting peroxisome proliferation, and ...
Ruonan Li, Huiyan Wang, Dunke Zhang, Qiuying Gu, Jinlong Wang, Bin Liu, Huabin Gao, Jingya Duan, Yimin Liu, Xiaolan Huang, Youquan Bu, Tongchuan He, Hua Linghu   +12 more
wiley   +1 more source

The reporting and handling of missing data in genetic epidemiological studies of mental health in childhood and adolescence: A systematic review

JCPP Advances, EarlyView.
Abstract Background Genetic epidemiological analyses of child and adolescent mental health often use data from prospective longitudinal cohorts. Missingness due to selective attrition is therefore an important potential source of bias in such analyses.
Meseret M. Bazezew, Adrian Dahl Askelund, Kate Tilling, Alexandra Havdahl, Laurie J. Hannigan   +4 more
wiley   +1 more source

Response to the Letter to Editor regarding: "High effectiveness of multilevel orthopedic surgery and guided growth in spastic hemiplegia children". [PDF]

J Child Orthop
Mamedov U, Dolganova T, Gatamov O, Foster P, Tomov A, Popkov D.   +5 more
europepmc   +1 more source

The core competencies in hospital medicine: Procedures 2025 update

Journal of Hospital Medicine, EarlyView.
Abstract This article presents an updated framework from the Society of Hospital Medicine for individual learning objectives related to key procedures in hospital medicine. Building upon the 2017 framework, these objectives have been revised to reflect evolving clinical evidence, advancements, and shifts in hospital medicine practice patterns.
Satyen Nichani, Megan E. Brooks, Christine Bryson, Nick Fitterman, Meltiady Issa, Michael Lukela, Nick Marzano, Kelly Sopko, Joseph R. Sweigart   +8 more
wiley   +1 more source

Construction and evaluation of a PONV prediction model in patients undergoing orthopedic surgery under spinal anesthesia: a prospective cohort study. [PDF]

BMC Anesthesiol
Zou Y, Li N, Li C, Wu Y, Tang X, Sun X, Ye Q.   +6 more
europepmc   +1 more source

A systematic review and meta-analysis on ketamine use and postoperative delirium in older patients undergoing spine or orthopedic surgery. [PDF]

Anesthesiol Perioper Sci
Sretavan A, Buren M, Tahir P, Leung JM.
europepmc   +1 more source

Tele‐hospitalist services to support the opening of a new rural hospital

Journal of Hospital Medicine, EarlyView.
Abstract As rural hospitals experiencing low patient volume and workforce shortages continue to close nationally, we present an innovative telemedicine care delivery model utilized to support the opening of a new 25‐bed rural hospital in South Carolina in 2023.
Yotam Papo, Jillian Harvey, Dunc Williams Jr., Kit N. Simpson, Jay Hinesley, Allen Abernethy, Dee W. Ford, Marc Heincelman   +7 more
wiley   +1 more source