Results 131 to 140 of about 169,349 (348)

Mechanical Load‐Induced Upregulation of Talin2 through Non‐Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis

Advanced Science, EarlyView.
Facet joint osteoarthritis (FJOA), prevalent in the elderly, involves Talin2 upregulation promoting ECM degradation while suppressing synthesis. Mechanical load stabilizes Talin2 via OTUB1‐mediated non‐canonical deubiquitination, driving CCL2 expression that recruits immune cells, exacerbating inflammatory joint degeneration.
Yizhen Huang, Heng Sun, Haojie Chen, Xiangpeng Wang, Junduo Zhao, Yang Jiao, Hongyi Zhou, Haoyu Cai, Jiafeng Dai, Xuan Huang, Weiyun Chen, Jianxiong Shen   +11 more
wiley   +1 more source

Bacterial Capture‐Killing Capsules with Remodeling Bone Immune Microenvironment for the Effective Treatment of Osteomyelitis

Advanced Science, EarlyView.
The PC‐O@TOB capsules are designed to exhibit bactericidal effects, regulate the bone immune microenvironment by promoting M2 macrophage polarization, eliminate excessive ROS, and enhance bone regeneration, providing a novel multi‐dimensional approach for the treatment of osteomyelitis.
Dong Yang, Chang Shu, Chengwei Xu, Xingjie Zan, Shaoyin Wei, Chenglong Wang, Lianxin Li   +6 more
wiley   +1 more source

Language Skills of Young Children with Unilateral Cleft Lip and Palate following Infant Orthopedics: A Randomized Clinical Trial [PDF]

, 2003
Emmy M. Konst, Toni Rietveld, Herman F.M. Peters, Anne Marie Kuijpers‐Jagtman   +3 more
openalex   +3 more sources

An Optimization-based Baseline for Rigid 2D/3D Registration Applied to Spine Surgical Navigation Using CMA-ES [PDF]

arXiv
A robust and efficient optimization-based 2D/3D registration framework is crucial for the navigation system of orthopedic surgical robots. It can provide precise position information of surgical instruments and implants during surgery. While artificial intelligence technology has advanced rapidly in recent years, traditional optimization-based ...
arxiv  

Development and prospects of digital orthopedics in Hubei province

Global Health Journal, 2019
Based on the development and application of new technology, as a new interdisciplinary subject, digital orthopedics becomes an important development direction of modern medicine in the past years.
Xinghuo Wu, Zhewei Ye
doaj  

SOME ASPECTS OF ORGANIZATION OF HIGH TECHNOLOGY MEDICAL AID RENDERING AT SARATOV SCIENTIFIC RESEARCH INSTITUTE OF TRAUMATOLOGY AND ORTHOPEDICS [PDF]

Саратовский научно-медицинский журнал, 2009
The article is devoted to the peculiarities of organization of high technology medical aid rendering at Saratov Scientific Research Institute of Traumatology and Orthopedics.
T.A. Shulgina, A.S. Kolmykova, M.A. Saakjan, E.V. Gladkova, S.P. Ilinykh, T. N. Akimova, V.V. Savchenko, I.A. Norkin   +7 more
doaj  

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis

Advanced Science, EarlyView.
Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...
Li Lu, Jiewen Liao, Chao Xu, Yuan Xiong, Juan Zhou, Guangji Wang, Ze Lin, Kangkang Zha, Chuanlu Lin, Ruiyin Zeng, Guandong Dai, Qian Feng, Bobin Mi, Guohui Liu   +13 more
wiley   +1 more source

More and better orthopedics in the year 2000 [PDF]

, 1991

openalex   +1 more source

Pre and postoperative analgesia for orthopedic surgeries

Revista Dor
BACKGROUND AND OBJECTIVES:Pain is frequent in wards and impairs patients’ treatment and recovery, especially orthopedic patients. So, this study aimed at evaluating pre and postoperative analgesic adequacy in patients submitted to orthopedic surgeries ...
Verônica Ferreira de Aguiar Kawai, Paulo José Oliveira Cortez, Vitor Engrácia Valenti, Fernando Rocha Oliveira, Luciano Magalhães Vitorino   +4 more
doaj   +1 more source

Electrochemical‐Genetic Programming of Protein‐Based Magnetic Soft Robots for Active Drug Delivery

Advanced Science, EarlyView.
This manuscript presents a protein‐based soft robot for active drug delivery. Stimuli‐responsive protein is rationally designed and processed into the substrate of robots. Superparamagnetic Fe3O4 nanoparticles are patterned on the substrate using an electrochemical method, enabling the robot to respond to external physical fields.
Hang Zhao, Bo Yu, Dingyi Yu, Ting Ji, Kexin Nie, Jingyi Tian, Xinchen Shen, Kaiyue Zhang, Junhan Ou, Xinyi Yang, Dongfang Xiao, Qi Zhou, Wenwen Huang   +12 more
wiley   +1 more source