Results 71 to 80 of about 23,038 (257)

Effects of Pulsed Electromagnetic Fields on Return to Sports After Arthroscopic Debridement and Microfracture of Osteochondral Talar Defects A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial

, 2016
Background: Osteochondral defects (OCDs) of the talus usually affect athletic patients. The primary surgical treatment consists of arthroscopic debridement and microfracture. Various possibilities have been suggested to improve the recovery process after
Meuffels, Duncan, Krips, R, Kerkhoffs, GMMJ, Gerards, RM, Reilingh, ML, de Haan, RJ, Sierevelt, IN, van Dijk, CN, van Eekeren, IC, van Bergen, CJA, Blankevoort, L   +10 more
core   +1 more source

Identifying the 'incredible'! Part 1: Assessing the risk of bias in outcomes included in systematic reviews [PDF]

, 2019
Introduction Systematic reviews fulfil a vital role in modern medicine.1 However, the results of systematic reviews are only as valid as the studies they include.2 Pooling flawed, or biased, results from different studies can compromise the credibility ...
Lura, C.B. (Carolina Bryne), Winters, M, Elbers, Roy,, Büttner, F. (Fionn), Weir, A, Weir, Adam,, Lura, Carolina B.,, Winters, Marinus, Buttner, Fionn,, Ardern, C.L. (Clare L.), Delahunt, E, Khan, Karim M.,, Elbers, R, Büttner, Fionn, Winters, M. (Marinus), Elbers, R. (Roy), Khan, KM, Winters, Marinus,, Lura, CB, Weir, A. (Adam), Delahunt, Eamonn, Ardern, Clare,, Khan, Karim M, Büttner, F, Ardern, Clare L, Weir, Adam, Elbers, Roy, Delahunt, E. (Eamonn), Delahunt, Eamonn,, Khan, K.M. (Karim M.), Lura, Carolina B, Ardern, CL   +31 more
core   +2 more sources

In Situ Stress‐Dispersing Hydrogel Millispheres via Load Redistribution to Restore Nucleus Pulposus Metabolic Homeostasis

Advanced Science, EarlyView.
Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li, Hui Yuan, Honglei Xiao, Xiaodong Liu, Wenguo Cui   +4 more
wiley   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source

Ultrasonographic tissue characterisation of human Achilles tendons: quantification of tendon structure through a novel non-invasive approach [PDF]

, 2009
OBJECTIVE: To asses if three-dimensional imaging of the Achilles tendon by Ultrasonographic Tissue Characterisation (UTC) can differentiate between symptomatic and asymptomatic tendons. DESIGN: Case-control study.
Tol, J. L., Jonge, S. (Suzan) de, Schie, J.T.M. (Hans) van, Verhaar, J.A.N. (Jan), van Schie, H. T. M., Bakker, E. M., Weinans, H., Vos, R.J. (Robert-Jan) de, Bakker, E.M. (Erwin), Verhaar, J. A. N., Heijboer, M.P. (Rien), de Vos, R. J., de Jonge, S., Tol, J.L. (Johannes), Heijboer, M. P., Weinans, H.H. (Harrie), Schie, Hans, de Vos, Robert-Jan, Heijboer, Rien, Verhaar, Jan, Jonge, Suzan, Bakker, Marije, Weinans, HH, Tol, JL   +23 more
core   +2 more sources

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

Ubiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid‐Induced Bone Loss

Advanced Science, EarlyView.
GCs reduce Parkin, leading to ACSL4 accumulation and PUFA‐phospholipid‐driven ferroptosis in BMSCs, which impairs osteogenesis and promotes adipogenesis, causing GIOP. Parkin restoration (via OE‐Parkin or Parkin‐LNP@DSS6) ubiquitinates and degrades ACSL4, inhibiting ferroptosis, rescuing bone formation, and rescues GIOP bone loss.
Li‐jiang Han, Jian‐sen Miao, Yi‐feng Shi, Yi‐ting Tu, Yu‐zhe Lin, Lin‐Jie Chen, Bing‐hao Lin, Hua‐lin Li, Xuan‐qi Zheng, Hong‐qiang Wu, Hai‐xiao Liu, Lei Yang, Ai‐min Wu, Zhen Lin, Jian Xiao, Gang Zheng, Chen Jin   +16 more
wiley   +1 more source

Progression of Hamate Hook Stress Reactions in Elite Baseball Players

Orthopaedic Journal of Sports Medicine, 2020
Background: Hamate hook fractures can occur as a result of repetitive contact with the knob of the bat used in the sport of baseball. Hamate hook excision has resulted in excellent outcomes and return to sport (RTS) in elite baseball players.
Kyle R. Sochacki MD, Shari R. Liberman MD, Thomas L. Mehlhoff MD, Jaclyn M. Jones BS, David M. Lintner MD, Patrick C. McCulloch MD   +5 more
doaj   +1 more source

Improving Equine Intramedullary Nail Osteosynthesis via Fracture Adjacent Polymer Reinforcement

Current Directions in Biomedical Engineering, 2022
Introduction: Osteosynthesis of the equine femur is still a challenge for veterinary medicine. Even though intramedullary fracture fixation is possible nowadays, the varying geometry of the medullary cavity along the bone axis is a critical factor ...
Lang Jan J., Baylacher Veronika, Micheler Carina M., Wilhelm Nikolas J., Hinterwimmer Florian, Schwaiger Benedikt, Barnewitz Dirk, Eisenhart-Rothe Rüdiger von, Grosse Christian U., Burgkart Rainer   +9 more
doaj   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source