Results 61 to 70 of about 18,143 (149)

A Method for Generating Toolpaths in the Manufacturing of Orthosis Molds with a Five-Axis Computer Numerical Control Machine

Machines
This paper proposes a new algorithm for the automatic generation of toolpaths for machining complex geometric positions, such as molds used in orthosis production.
Karlo Obrovac, Pero Raos, Tomislav Staroveški, Danko Brezak   +3 more
doaj   +1 more source

Intramuscular botulinum toxin prior to comprehensive rehabilitation has no added value for improving motor impairments, gait kinematics and goal attainment in walking children with spastic cerebral palsy

Journal of Rehabilitation Medicine, 2018
Objective: Botulinum toxin (BoNT-A) is widely used in combined treatment for spastic cerebral palsy, but its added value preceding comprehensive rehabilitation for motor impairments, gait, and goal attainment has not been studied.
Fabienne Schasfoort, Robert Pangalila, Emiel M. Sneekes, Coriene Catsman, Jules Becher, Herwin Horemans, Henk J. Stam, Annet J. Dallmeijer, Johannes B.J Bussmann   +8 more
doaj   +1 more source

Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Primary pyruvate dehydrogenase complex deficiency (PDCD) comprises a group of monogenic disorders caused by pathogenic variants in genes encoding subunits of, or regulatory components affecting, the pyruvate dehydrogenase complex. The clinical phenotype spans a broad continuum, ranging from early onset congenital lactic acidosis to infantile ...
Nandaki Keshavan, Julia Neugebauer, Marcello Bellusci, Enrico Bertini, Garry Brown, Niklas Darin, Suzanne DeBrosse, Lucy Drexler, Stefan Drexler, Gregory M. Enns, Rebecca D. Ganetzky, Kelly Gilbert, Austin Larson, Rebecca Legi, April N. Lehman, Camile Newby, Manuel Schiff, Rachel Skeath, Peter W. Stacpoole, Sarah Thompson, Emma Watt, Saskia B. Wortmann, Jirair K. Bedoyan, Shamima Rahman   +23 more
wiley   +1 more source

Efficacy and safety of cannabinoids in the treatment of spasticity in multiple sclerosis: A systematic review of randomized clinical trials

British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3288-3300, October 2026.
Aims This work aimed to evaluate the efficacy and safety of cannabinoids for the treatment of MS‐related spasticity. Methods Systematic searches were conducted in PubMed, EMBASE, and LILACS on 2 December 2025. Randomized controlled trials evaluating natural or synthetic cannabinoids for MS‐related spasticity were included.
Letícia Hamm‐Buiar, Daniela Gorski, Marcela Harumi Kagueiama, Astrid Wiens   +3 more
wiley   +1 more source

Efficacy, Effectiveness, and Efficiency of Nurse‐Led Interventions: Insights From a Critical Systematic Review

Nursing Inquiry, Volume 33, Issue 4, October 2026.
ABSTRACT Healthcare systems worldwide face mounting pressure to deliver high‐quality care while enhancing efficiency and sustainability. Nurse‐led interventions have emerged as promising strategies to optimize care delivery, particularly within value‐based health systems.
Aleix Fontanals‐Jimenez, Marta Trapero‐Bertran, Esther Insa‐Calderón   +2 more
wiley   +1 more source

Prevalence of 21 Physician‐Defined Severe Toxicities Following Childhood Acute Lymphoblastic Leukemia Treatment: Australian Retrospective Cohort Study

Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.
ABSTRACT Background Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, with an overall survival now surpassing 90% in developed countries. However, treatments are not without adverse effects. In this study, we apply the severe toxicity‐free survival (STFS) framework to determine the prevalence of 21 physician‐defined severe ...
Lane Collier, Brittany Grantham, Camilla Grud Nielsen, Louise Lundgren, Liv Andrés‐Jensen, Kjeld Schmiegelow, Chris Selman, Gareth Ball, Elyse Passmore, David A. Elliott, Rachel Conyers   +10 more
wiley   +1 more source

Long‐Term Follow Up of Two Patients With Variants in the Cluster 1031‐1159 of TRRAP Gene: Expanding the Phenotype of Developmental Delay With or Without Dysmorphic Facies and Autism

American Journal of Medical Genetics Part A, Volume 200, Issue 9, Page 2099-2105, September 2026.
ABSTRACT The transformation/transcription domain‐associated protein (TRRAP) gene encodes a large multidomain protein, a member of the phosphatidylinositol 3‐kinase‐related kinase (PIKK) family. TRRAP is a component of the histone acetyltransferase (HAT) complex, and it plays an important role in gene transcription, DNA repair, and cell‐cycle regulation.
Roseli Maria Zechi‐Ceide, Vinicius Contrucci Dantas Segarra, Siulan Vendramini‐Pittoli, Henrique Regonaschi Serigatto, Luiza Virmond, Heloisa Marcelina da Cunha Palhares, Fernanda Jehee, Ana Cristina Victorino Krepischi, Carla Rosenberg, Carlos Henrique Paiva Grangeiro, Nancy Mizue Kokitsu‐Nakata   +10 more
wiley   +1 more source

Clinical Efficacy and Accuracy of 3D‐Printed Medical Devices: A Systematic Review and Meta‐Analysis

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Aim This systematic review aimed to assess the clinical and experimental utility of three‐dimensional (3D) printing in medical and dental applications, with a focus on its impact on surgical precision, procedural efficiency, and patient‐centered results.
Vishnu Priya Veeraraghavan, Krishna Mohan Surapaneni, Seyed Ali Mosaddad   +2 more
wiley   +1 more source

Australian Research Related to Sporting and Musculoskeletal Injuries of the Foot and Ankle: A Bibliometric Analysis

Journal of Foot and Ankle Research, Volume 19, Issue 3, September 2026.
ABSTRACT Background There is growing research evidence related to musculoskeletal and sports podiatry published by Australian researchers. This short report presents data from the musculoskeletal and sports podiatry stream of a national bibliometric review which aimed to map all Australian podiatry‐related research from 1970 to 2024.
Benjamin Peterson, John Osborne, Ameer Nor Azhar, Matthew Carroll, Peta Tehan   +4 more
wiley   +1 more source

Description of orthotic properties and effect evaluation of ankle-foot orthoses in non-spastic calf muscle weakness

Journal of Rehabilitation Medicine
Objective: To describe the orthotic properties and evaluate the effects of ankle-foot orthoses for calf muscle weakness in persons with non-spastic neuromuscular disorders compared with shoes-only. Design: Cross-sectional study.
Niels F.J. Waterval, Merel-Anne Brehm, Jaap Harlaar, Frans Nollet   +3 more
doaj   +1 more source