Results 41 to 50 of about 136,333 (335)

Orthostatic Hypotension: A Prodromal Marker of Parkinson's Disease?

Movement Disorders, 2020
Orthostatic hypotension is common in patients with Parkinson's disease (PD). However, it remains unknown whether orthostatic hypotension is a marker of prodromal PD or more advanced disease. The objectives of this study were to assess whether orthostatic
L. Dommershuijsen, A. Heshmatollah, Francesco U.S. Mattace Raso, P. Koudstaal, M. A. Ikram, M. Ikram   +5 more
semanticscholar   +1 more source

The hypotensive effect of activated apelin receptor is correlated with \b{eta}-arrestin recruitment [PDF]

Elie Besserer-Offroy, et al. Pharmacol Res, Epub 9 March 2018, 2018
The apelinergic system is an important player in the regulation of both vascular tone and cardiovascular function, making this physiological system an attractive target for drug development for hypertension, heart failure and ischemic heart disease.
arxiv   +1 more source

Postural changes in optic nerve and optic nerve sheath diameters in postural orthostatic tachycardia syndrome and spontaneous intracranial hypotension: A cohort study.

PLoS ONE, 2019
BackgroundPostural orthostatic tachycardia syndrome is a disorder of the autonomic nervous system. Approximately 30% of patients experience orthostatic headaches.
Debora Cipriani, Belén Rodriguez, Levin Häni, Raya Zimmermann, Jens Fichtner, Christian T Ulrich, Andreas Raabe, Jürgen Beck, Werner J Z'Graggen   +8 more
doaj   +1 more source

Pharmacological Treatment of Postprandial Reductions in Blood Pressure : A Systematic Review [PDF]

, 2015
Funded by The Dunhill Medical Trust.
Alam, Aronow, Freeman, Gentilcore, Heseltine, Heseltine, Hirayama, Jansen, Jansen, Jansen, Jansen, Jian, Jones, Jones, Lenders, Lipsitz, Lipsitz, Moher, O'Donovan, Onrot, Potter, Rakic, Russo, Sawynok, Shibao, Vaitkevicius, Visvanathan, Vloet, Vloet   +28 more
core   +1 more source

Fludrocortisone for orthostatic hypotension

Cochrane Database of Systematic Reviews, 2017
Orthostatic hypotension is an excessive fall in blood pressure (BP) while standing and is the result of a decrease in cardiac output or defective or inadequate vasoconstrictor mechanisms. Fludrocortisone is a mineralocorticoid that increases blood volume and blood pressure. Fludrocortisone is considered the first- or second-line pharmacological therapy
Stephanie Veazie, Kim Peterson, Satish R Raj, Mark Helfand, Yasmin Ansari, Christopher H. Gibbons, Kathryn A. Chung   +6 more
openaire   +4 more sources

Identifying Decision Points for Safe and Interpretable Reinforcement Learning in Hypotension Treatment [PDF]

arXiv, 2021
Many batch RL health applications first discretize time into fixed intervals. However, this discretization both loses resolution and forces a policy computation at each (potentially fine) interval. In this work, we develop a novel framework to compress continuous trajectories into a few, interpretable decision points --places where the batch data ...
arxiv  

Neurovisceral phenotypes in the expression of psychiatric symptoms [PDF]

, 2015
This review explores the proposal that vulnerability to psychological symptoms, particularly anxiety, originates in constitutional differences in the control of bodily state, exemplified by a set of conditions that include Joint Hypermobility, Postural ...
Aktas, Al-Rawi, Anderson, Andrew P. Owens, Arunkalaivanan, Baeza-Velasco, Bagai, Bayles, Beacher, Benarroch, Bendik, Benrud-Larson, Birner, Boddaert, Bohora, Bovell, Bulbena, Bulbena, Bulbena, Bulbena, Bulbena, Bulbena, Buodo, Castori, Child, Christopher J. Mathias, Cohen, Critchley, Critchley, Critchley, De Kort, De Wandele, Eccles, Eccles, Eccles, Ekman, Engel, Esler, Esler, Fenton, Friedman, Fu, Ganzeboom, Garcia Campayo, Gazit, Giada, Gracie, Grahame, Grahame, Grubb, Hakim, Hakim, Hugo D. Critchley, Hunt, Jessica A. Eccles, Joyner, Kanjwal, Kapoor, Karaca, Karan, Kaya, Kelly, Khurana, Khurana, Kirby, Koldas Dogan, Kouakam, Lader, Lambert, Lammers, Lee, Leftheriotis, Lemche, Lemche, Lewis, Lewis, Linzer, Lonsdale-Eccles, Low, Luborsky, Mallorqui-Bague, Martin-Santos, Masuki, Mathias, Mathias, Mayer-Gross, McGrady, Milhorat, Mohammed, Morgan, Mulvey, Nicotra, Nijs, Noppen, Ocon, Ocon, Ofluoglu, Ojha, Parsaik, Paulus, Peggs, Phillips, Porges, Pritchard, Raj, Raj, Ramos, Ross, Rozen, Sanches, Satoshi Umeda, Savage, Schievink, Schondorf, Seth, Sierra, Sierra, Sierra, Simeon, Sledge, Smith, Stachenfeld, Stewart, Stoler, Tinkle, Tracey, Umeda, Ventura, Vounotrypidis, Wooley, Yazici, Zarate, Zysko   +132 more
core   +4 more sources

Squamous Carcinoma of the Lung Presenting as Migraine-Type Headache: A Case Report

Case Reports in Oncology, 2015
Introduction: Orthostatic hypotension has long been recognised as a paraneoplastic effect of lung cancer. Lung cancer presenting with orthostatic hypotension and migraine-type headaches has not been previously described in the literature.
Eswaran Waran
doaj   +1 more source

Postural Orthostatic Tachycardia Syndrome explained using abaroreflex response model [PDF]

arXiv, 2021
Recent studies have shown that Postural Orthostatic Tachycardia Syndrome (POTS) patients have abnormal low frequency $\approx 0.1$ Hz blood pressure and heart rate dynamics. These dynamics are attributed to the baroreflex and can give insight into the mechanistic causes which are the basis for proposed subgroups of POTS.
arxiv  

First‐in‐human safety, tolerability, pharmacokinetics and pilot food‐effect study of the candidate antimalarial compound MMV367

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Andrea Kuemmerle, Nand Singh, Denis Gossen, Annick Janin, Raman Sharma, Anthony Cahn, Rachel A. Gibson, Somasekhara R. Menakuru, Erin Lambourne, Tom Dove, Francisco‐Javier Gamo, Laura Sanz, Benoit Bestgen, Stephan Chalon   +13 more
wiley   +2 more sources