Results 1 to 10 of about 8,142 (147)

Orthostatic vital signs do not predict 30 day serious outcomes in older emergency department patients with syncope: A multicenter observational study. [PDF]

Am J Emerg Med, 2019
Syncope is a common chief complaint among older adults in the Emergency Department (ED), and orthostatic vital signs are often a part of their evaluation. We assessed whether abnormal orthostatic vital signs in the ED are associated with composite 30-day serious outcomes in older adults presenting with syncope.We performed a secondary analysis of a ...
White JL, Hollander JE, Chang AM, Nishijima DK, Lin AL, Su E, Weiss RE, Yagapen AN, Malveau SE, Adler DH, Bastani A, Baugh CW, Caterino JM, Clark CL, Diercks DB, Nicks BA, Shah MN, Stiffler KA, Storrow AB, Wilber ST, Sun BC.   +20 more
europepmc   +7 more sources

Clinical Assessment of Fluid Status in Adults With Acute Kidney Injury: A Scoping Review. [PDF]

J Ren Care
ABSTRACT Background Acute kidney injury refers to sudden, potentially reversible, reduction in kidney function. Hypovolaemia is commonly the major risk factor. When acute kidney injury is established, fluid can accumulate leading to fluid overload. Undertaking a rigorous fluid assessment is vital in the management of a patient in hospital with acute ...
Nagalingam K, Whiting L, Farrington K, Migliozzi J, Pattison N.   +4 more
europepmc   +2 more sources

First-in-human safety, tolerability, pharmacokinetics and pilot food-effect study of the candidate antimalarial compound MMV367. [PDF]

Br J Clin Pharmacol
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Kuemmerle A, Singh N, Gossen D, Janin A, Sharma R, Cahn A, Gibson RA, Menakuru SR, Lambourne E, Dove T, Gamo FJ, Sanz L, Bestgen B, Chalon S.   +13 more
europepmc   +2 more sources

Dehydration and Orthostatic Vital Signs in Women with Hyperemesis Gravidarum [PDF]

Academic Emergency Medicine, 1995
ABSTRACTObjectives: To assess the hydration status of women presenting to an ED with hyperemesis gravidarum and to determine whether clinically relevant changes in orthostatic vital signs occur.Methods: A convenience sample of 23 pregnant women who had hyperemesis gravidarum, with each patient serving as her own control.
Daniel Douglas, Daniel Douglas, David R. Johnson, David R. Johnson, Mark Hauswald, Mark Hauswald, Dan Tandberg, Dan Tandberg   +7 more
openaire   +4 more sources

Orthostatic Vital Signs in Bone Marrow Transplant Patients [PDF]

, 2023
Background: Orthostatic hypotension is a potentially serious risk factor that can cause falls in adults, especially those receiving a bone marrow transplant.
Tomac, Julianne
core   +1 more source

Utilizing the Boston Syncope Observation Management Pathway to Reduce Hospital Admission and Decrease Adverse Outcomes [PDF]

, 2019
Introduction: In an age of increasing scrutiny of each hospital admission, emergency department (ED) observation has been identified as a low-cost alternative. Prior studies have shown admission rates for syncope in the United States to be as high as 70%.
Grossman, Shamai A., Lopez, Gregory J., Mechanic, Oren J., Pascheles, Celine Y., Shapiro, Nathan I., Tibbles, Carrie, Winans, Alina M., Wolfe, Richard E.   +7 more
core   +2 more sources

Neurovisceral phenotypes in the expression of psychiatric symptoms [PDF]

, 2015
This review explores the proposal that vulnerability to psychological symptoms, particularly anxiety, originates in constitutional differences in the control of bodily state, exemplified by a set of conditions that include Joint Hypermobility, Postural ...
Aktas, Al-Rawi, Anderson, Andrew P. Owens, Arunkalaivanan, Baeza-Velasco, Bagai, Bayles, Beacher, Benarroch, Bendik, Benrud-Larson, Birner, Boddaert, Bohora, Bovell, Bulbena, Bulbena, Bulbena, Bulbena, Bulbena, Bulbena, Buodo, Castori, Child, Christopher J. Mathias, Cohen, Critchley, Critchley, Critchley, De Kort, De Wandele, Eccles, Eccles, Eccles, Ekman, Engel, Esler, Esler, Fenton, Friedman, Fu, Ganzeboom, Garcia Campayo, Gazit, Giada, Gracie, Grahame, Grahame, Grubb, Hakim, Hakim, Hugo D. Critchley, Hunt, Jessica A. Eccles, Joyner, Kanjwal, Kapoor, Karaca, Karan, Kaya, Kelly, Khurana, Khurana, Kirby, Koldas Dogan, Kouakam, Lader, Lambert, Lammers, Lee, Leftheriotis, Lemche, Lemche, Lewis, Lewis, Linzer, Lonsdale-Eccles, Low, Luborsky, Mallorqui-Bague, Martin-Santos, Masuki, Mathias, Mathias, Mayer-Gross, McGrady, Milhorat, Mohammed, Morgan, Mulvey, Nicotra, Nijs, Noppen, Ocon, Ocon, Ofluoglu, Ojha, Parsaik, Paulus, Peggs, Phillips, Porges, Pritchard, Raj, Raj, Ramos, Ross, Rozen, Sanches, Satoshi Umeda, Savage, Schievink, Schondorf, Seth, Sierra, Sierra, Sierra, Simeon, Sledge, Smith, Stachenfeld, Stewart, Stoler, Tinkle, Tracey, Umeda, Ventura, Vounotrypidis, Wooley, Yazici, Zarate, Zysko   +132 more
core   +2 more sources

The effect of elastic abdominal binder use on respiratory function on persons with high spinal cord injury at orthostatic position [PDF]

, 2015
Introduction : Spinal cord injury causes respiratory muscles paralysis, especially in high thoracic paraplegia and tetraplegia with injury above or right on the sixth thoracic segment, and also biomechanics, volumes, capacities and respiratory pressures ...
Cardoso, Jefferson R., da Silva, Rubens Alexandre, de Souza Pinho Costa, Viviane, Moreira da Costa Filho, Ruy, Teixeira Costa, Bianca   +4 more
core   +1 more source

Randomised clinical trial: Polyethylene glycol 3350 with sports drink vs. polyethylene glycol with electrolyte solution as purgatives for colonoscopy--the incidence of hyponatraemia. [PDF]

, 2014
BACKGROUND: Polyethylene glycol 3350 plus sports drink (PEG-SD) is a hypo-osmotic purgative commonly used for colonoscopy, though little safety data are available. AIM: To evaluate the effect of PEG-SD on serum sodium (Na) and other electrolytes compared
Aronchick, Ayus, Beck, Cohen, Drossman, Ell, Ellison, Goodman, Katz, Lewis, Malik, Nagler, Rao, Rex, Rex, Samarasena, Seeff, Surget, Zimmerman   +18 more
core   +2 more sources

First‐in‐Human Single and Multiple Ascending Dose Studies of Balinatunfib, a Small Molecule Inhibitor of TNFR1 Signaling in Healthy Participants

Clinical Pharmacology &Therapeutics, EarlyView.
Oral small molecule inhibitors of tumor necrosis factor alpha (TNFα) are emerging as attractive therapeutic agents for the treatment of various autoimmune diseases. Balinatunfib (SAR441566), a novel oral inhibitor of tumor necrosis factor receptor 1 (TNFR1) signaling, changes the configuration of the soluble TNFα (sTNFα) trimer and prevents its ...
Nassr Nassr, Faiza Rharbaoui, Dietmar Weitz, Johann Gassenhuber, Markus Rehberg, Markus Kohlmann, Fabienne Schumacher, Amel Lahmar, Andreas Kovar, Laurent Perrin, Frank‐Dietrich Wagner, Maria Wiekowski, Mai Anh Nguyen   +12 more
wiley   +1 more source