Results 51 to 60 of about 9,571 (180)
Comprehensive Physiology, Volume 16, Issue 2, April 2026.Vagus nerve stimulation (VNS) effects span central and peripheral organ systems through diverse mechanistic pathways. This comprehensive review provides a unified synthesis of these mechanisms across neurological, cardiovascular, immunological, metabolic, and gastrointestinal domains, filling a critical gap and serving as a foundational resource for ...
Yifeng Bu +11 more
wiley +1 more source
The Journal of Clinical Pharmacology, Volume 66, Issue 4, April 2026.Abstract Macitentan is an oral, dual ETA/ETB endothelin receptor antagonist, currently approved in adults for the treatment of pulmonary arterial hypertension (PAH) at a once‐daily dose of 10 mg. Pre‐clinical and clinical data suggest that greater ETB receptor inhibition may result in greater efficacy.
Dénes Csonka +5 more
wiley +1 more source
Acid–Base Dysregulation Links Aging Metabolism to Frailty
Aging Cell, Volume 25, Issue 4, April 2026.Our Metabolic Buffer Model posits that chronic acid load from aging and accumulated stressors depletes total acid buffer reserve, disrupting intersystem crosstalk. This hidden homeostatic erosion drives clinical frailty and underlies homeostatic failure during stress, unifying Rockwood's deficit accumulation and Fried's phenotype models.
Wan‐Hui Liao +2 more
wiley +1 more source
Journal of Human Nutrition and Dietetics, Volume 39, Issue 2, April 2026.ABSTRACT Introduction Avoidant‐restrictive food intake disorder (ARFID) is an eating disorder diagnosis implemented with DSM‐5 in 2013. Elevated risk for ARFID in patients with gastrointestinal disorders is suggested. This systematic review explored (1) methods used to identify patients with gastrointestinal disorders and comorbid ARFID and (2) their ...
Sissel Bekker Henriksen +2 more
wiley +1 more source
The effect of bedrest on various parameters of physiological function. part vi- the effect of the performance of periodic flack maneuvers on preventing cardiovascular deconditioning of bedrest [PDF]
Preventing cardiovascular deconditioning of bedrest by periodic Flack maneuvers - physiological performance and ...
Cardus, D. +3 more
core +1 more source
Impaired peripheral oxygen delivery during submaximal exercise in adults with long COVID
Physiological Reports, Volume 14, Issue 8, April 2026.Abstract Long COVID (LC) is a multisystem condition that is linked to distinct pathologies including viral persistence, immunological dysfunction, endothelial damage, and mitochondrial dysfunction. To date, limited research has assessed peripheral tissue hypoxia to better understand LC symptom exacerbation. Forty‐six people with LC and 10 controls (CON)
Callum Thomas +6 more
wiley +1 more source
International Journal of Eating Disorders, Volume 59, Issue 3, Page 501-509, March 2026.ABSTRACT Objective Program‐led and focused models may overcome structural barriers to accessing ED care, such as limited availability, for youth with EDs by prioritizing strategic, evidence‐based care delivered through a structured approach. The Rapid Intervention to Support Eating Issues (RISE) pilot aimed to promote weight restoration and prevent ...
Michele Calderoni +9 more
wiley +1 more source
Adaptation to prolonged bedrest in man: A compendium of research [PDF]
A compilation of major studies that describe the clinical observations and elucidate the physiological mechanisms of the adaptive process of man undergoing prolonged bed rest is presented.
Dorchak, K. J. +3 more
core +1 more source
Vaccines in Current Culture: The HPV Vaccine Controversy [PDF]
, 2020 The use of vaccinations has drastically decreased mortality and morbidity rates related to infectious disease and has become an intrinsic part of modern health care.
Johnston, Alyssa
core +1 more source
Effects of Weightlessness on Man During U. S. Suborbital and Orbital Flights [PDF]
Human responses to weightlessness - analysis of astronaut biomedical data from Mercury project ...
Gerathewohl, S. J.
core +1 more source