Results 131 to 140 of about 50,612 (311)

Targeting SPP1‐CD44‐Hedgehog Axis Elicits Therapeutic Effects in Hepatocellular Carcinoma by Suppressing Intratumoral Fibrosis

Cancer Science, EarlyView.
SPP1 was identified as a key driver of intratumoral fibrosis and hepatocellular carcinoma (HCC) progression through transcriptomic, histological, and functional analyses. Mechanistically, SPP1 promotes HSC activation and fibrosis via the SPP1–CD44–GLI1 axis, and pharmacologic inhibition of Hedgehog signaling effectively reduces tumor growth and ...
Atsushi Nara, Shu Shimada, Yoshimitsu Akiyama, Megumi Hatano, Yusuke Chino, Suguru Miyazawa, Hanako Tamura, Daisuke Asano, Yoshiya Ishikawa, Hiroki Ueda, Shuichi Watanabe, Eriko Katsuta, Keiichi Akahoshi, Kenichi Ohashi, Minoru Tanabe, Daisuke Ban, Shinji Tanaka   +16 more
wiley   +1 more source

Value of T-tube in biliary tract reconstruction during orthotopic liver transplantation: a meta-analysis [PDF]

, 2011
Weidong Huang, Jiu-kun Jiang, Yuan‐Qiang Lu   +2 more
openalex   +1 more source

Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant Population [PDF]

, 2021
Taryn A Eubank, Constance M. Mobley, Mozhgon Moaddab, Mark J. Hobeika, Melissa O’Neal, William L. Musick, Joshua M. Knight, Joseph Galati, Sudha Kodali, Akshay Shetty, David W. Victor, Ashish Saharia, R. Mark Ghobrial, Kevin A. Grimes   +13 more
openalex   +1 more source

Targeting Wnt3a and Loxl2 Synergistically Induces Ferroptosis in Liver Cancer Stem Cells and Suppresses Tumorigenesis

Cancer Science, EarlyView.
Using bioinformatic analysis, LCSC models, and transgenic mice, we demonstrate that co‐inhibition of Wnt3a and Loxl2 potently triggers ferroptosis and inhibits orthotopic liver tumorigenesis. The enhanced antitumor effect upon dual targeting, mediated through ZEB1 upregulation, highlights a promising combinatory approach against HCC.
Guanghui Ren, Qingwei Cong, Jing Wang, Wenyue Gao, Yunpeng Guan, Lianxin Zhu, Ying Zhu   +6 more
wiley   +1 more source

SUSD2 Promotes Metastasis and Primary Tumor Growth in Pancreatic Cancer Cells via Integrin–FAK Signaling Activation

Cancer Science, EarlyView.
This study investigates the role of Sushi domain‐containing 2 (SUSD2) in pancreatic ductal adenocarcinoma (PDAC) and demonstrates that SUSD2 enhances both metastasis and primary tumor growth by promoting integrin β1–FAK signaling. SUSD2 interacts with integrin β1, enhancing adhesion to extracellular matrix (ECM) components such as collagen 1 and ...
Junjiro Yoshida, Tomokazu Ohishi, Isao Momose, Shun‐ichi Ohba, Kyohei Kurosawa, Akiko Harakawa, Hiroyuki Inoue, Minori Senoo, Daisuke Tatsuda, Hikaru Abe, Atsushi Masamune, Manabu Kawada   +11 more
wiley   +1 more source

Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis

, 2021
José Carlos Rodrigues Nascimento, Lianna Cavalcante Pereira, Juliana Magalhães da Cunha Rêgo, Ronaldo Pereira Dias, Paulo Goberlânio B Silva, Silvio Alencar C Sobrinho, Gustavo Coelho, Ivelise Regina Canito Brasil, Edmilson Ferreira de Oliveira-Filho, James S. Owen, Pierluigi Toniutto, Reinaldo B. Oriá   +11 more
openalex   +1 more source

Cancer‐Specific Antihuman Podoplanin Antibody chLpMab‐2f Exerts Antitumor Effects Against Pleural Mesothelioma

Cancer Science, EarlyView.
Cancer‐specific antihuman podoplanin antibody chLpMab‐2f exerted antibody‐dependent cellular cytotoxicity and complement‐dependent cytotoxicity against pleural mesothelioma (PM) cell lines. Additionally, chLpMab‐2f inhibited tumor progression in mice with subcutaneously and intrathoracically transplanted human PM cells.
Aito Yoshida, Shinji Abe, Toshihiro Izumi, Satoshi Itakura, Keichiro Yamada, Takuya Wada, Takaaki Yamamoto, Chiemi Sato, Atsushi Mitsuhashi, Hirokazu Ogino, Seidai Sato, Tsutomu Shinohara, Masaki Hanibuchi, Mika K. Kaneko, Yukinari Kato, Yasuhiko Nishioka   +15 more
wiley   +1 more source

Orthotopic Heart and Combined Heart Liver Transplantation: the Ultimate Treatment Option for Failing Fontan Physiology [PDF]

, 2021
Leigh Reardon, Jeannette P. Lin, Glen S. VanArsdell, Fady M. Kaldas, Gentian Lluri, Weiyi Tan, Katrina M. Whalen, Daniel Cruz, Ali Nsair, Mario C. Deng, Melissa Moore, Hillel Laks, Reshma Biniwale, Sammy Saab, Andrew J. Baird, James M. Wilson, Lorraine Lubin, Jure Marijic, Tiffany M. Williams, Christopher Wray, Joseph Meltzer, Vadim Gudzenko, Wolf B. Kratzert, Jacques Neelankavil, Robert S. Venick, Jamil Aboulhosn   +25 more
openalex   +1 more source

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response

The FEBS Journal, EarlyView.
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo, Juan García‐Sáez, María Figueroa‐Fuentes, Annalisa Addante, Cesáreo Roncero, Nerea Lazcanoiturburu, Beatriz Pacheco, Julián Sanz, Cristina Gato, Eva Fernández‐Calderón, María de la O López, Águeda González‐Rodríguez, Almudena Porras, Flavio Maina, Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez   +16 more
wiley   +1 more source

Pretransplant depression, antidepressant use, and outcomes of orthotopic liver transplantation

, 2010
Shari S. Rogal, Douglas Landsittel, Owen S. Surman, Raymond T. Chung, Anna Rutherford   +4 more
openalex   +2 more sources